Combination treatment for ventilator-associated pneumonia in neonatal infants
The paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens w...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2016-04-01
|
| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/310 |
| Summary: | The paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens were susceptible to linezolid (its minimal inhibitory concentration was ≤ 4 µg/ml). The drug was used in combination with β-lactam antibiotics or aminoglycosides. All the infants displayed positive microbiological changes. Clinical effectiveness was noted in 95% of the newborn infants. There was secondary infection with gram-negative microorganisms in 25 cases and that with Enterococcus faecalis autostrains in 2 preterm infants. |
|---|---|
| ISSN: | 1027-4065 2500-2228 |