Combination treatment for ventilator-associated pneumonia in neonatal infants
The paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2016-04-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/310 |
| _version_ | 1797875277946159104 |
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| author | M. V. Kushnareva A. Yu. Gerasimov G. M. Dementieva E. S. Keshishian T. S. Okuneva |
| author_facet | M. V. Kushnareva A. Yu. Gerasimov G. M. Dementieva E. S. Keshishian T. S. Okuneva |
| author_sort | M. V. Kushnareva |
| collection | DOAJ |
| description | The paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens were susceptible to linezolid (its minimal inhibitory concentration was ≤ 4 µg/ml). The drug was used in combination with β-lactam antibiotics or aminoglycosides. All the infants displayed positive microbiological changes. Clinical effectiveness was noted in 95% of the newborn infants. There was secondary infection with gram-negative microorganisms in 25 cases and that with Enterococcus faecalis autostrains in 2 preterm infants. |
| first_indexed | 2024-04-10T01:45:06Z |
| format | Article |
| id | doaj.art-ef53a8bdc49d4f5f9e697387aaaecbff |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:45:06Z |
| publishDate | 2016-04-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-ef53a8bdc49d4f5f9e697387aaaecbff2023-03-13T09:12:42ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282016-04-01612929910.21508/1027-4065-2016-61-2-92-99301Combination treatment for ventilator-associated pneumonia in neonatal infantsM. V. Kushnareva0A. Yu. Gerasimov1G. M. Dementieva2E. S. Keshishian3T. S. Okuneva4ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава РФРодильный дом №15 Городской клинической больницы №13ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава РФОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава РФОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава РФThe paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens were susceptible to linezolid (its minimal inhibitory concentration was ≤ 4 µg/ml). The drug was used in combination with β-lactam antibiotics or aminoglycosides. All the infants displayed positive microbiological changes. Clinical effectiveness was noted in 95% of the newborn infants. There was secondary infection with gram-negative microorganisms in 25 cases and that with Enterococcus faecalis autostrains in 2 preterm infants.https://www.ped-perinatology.ru/jour/article/view/310новорожденныегоспитальная инфекция вентилятор-ассоциированная пневмония этиологиялинезолидлечение |
| spellingShingle | M. V. Kushnareva A. Yu. Gerasimov G. M. Dementieva E. S. Keshishian T. S. Okuneva Combination treatment for ventilator-associated pneumonia in neonatal infants Rossijskij Vestnik Perinatologii i Pediatrii новорожденные госпитальная инфекция вентилятор-ассоциированная пневмония этиология линезолид лечение |
| title | Combination treatment for ventilator-associated pneumonia in neonatal infants |
| title_full | Combination treatment for ventilator-associated pneumonia in neonatal infants |
| title_fullStr | Combination treatment for ventilator-associated pneumonia in neonatal infants |
| title_full_unstemmed | Combination treatment for ventilator-associated pneumonia in neonatal infants |
| title_short | Combination treatment for ventilator-associated pneumonia in neonatal infants |
| title_sort | combination treatment for ventilator associated pneumonia in neonatal infants |
| topic | новорожденные госпитальная инфекция вентилятор-ассоциированная пневмония этиология линезолид лечение |
| url | https://www.ped-perinatology.ru/jour/article/view/310 |
| work_keys_str_mv | AT mvkushnareva combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants AT ayugerasimov combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants AT gmdementieva combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants AT eskeshishian combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants AT tsokuneva combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants |