Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications
Enzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one of the first causes of several diseases, i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-06-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/15/6/173 |
| _version_ | 1811186386867322880 |
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| author | Nadia Ruocco Susan Costantini Flora Palumbo Maria Costantini |
| author_facet | Nadia Ruocco Susan Costantini Flora Palumbo Maria Costantini |
| author_sort | Nadia Ruocco |
| collection | DOAJ |
| description | Enzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one of the first causes of several diseases, including cancers. In the last several years, enzyme inhibitors, being good candidates as drugs in the pathogenic processes, have received an increasing amount of attention for their potential application in pharmacology. The marine environment is considered a challenging source of enzyme inhibitors for pharmacological applications. In this review, we report on secondary metabolites with enzyme inhibitory activity, focusing our attention on marine sponges and bacteria as promising sources. In the case of sponges, we only reported the kinase inhibitors, because this class was the most representative isolated so far from these marine organisms. |
| first_indexed | 2024-04-11T13:44:38Z |
| format | Article |
| id | doaj.art-ef53d41256f846bfbad936a58a1bfaf9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:44:38Z |
| publishDate | 2017-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ef53d41256f846bfbad936a58a1bfaf92022-12-22T04:21:08ZengMDPI AGMarine Drugs1660-33972017-06-0115617310.3390/md15060173md15060173Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological ApplicationsNadia Ruocco0Susan Costantini1Flora Palumbo2Maria Costantini3Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, ItalyUnità di Farmacologia Sperimentale, Istituto Nazionale Tumori “Fondazione G. Pascale”, IRCCS, 80131 Napoli, ItalyDepartment of Integrative Marine Ecology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, ItalyDepartment of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, ItalyEnzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one of the first causes of several diseases, including cancers. In the last several years, enzyme inhibitors, being good candidates as drugs in the pathogenic processes, have received an increasing amount of attention for their potential application in pharmacology. The marine environment is considered a challenging source of enzyme inhibitors for pharmacological applications. In this review, we report on secondary metabolites with enzyme inhibitory activity, focusing our attention on marine sponges and bacteria as promising sources. In the case of sponges, we only reported the kinase inhibitors, because this class was the most representative isolated so far from these marine organisms.http://www.mdpi.com/1660-3397/15/6/173enzyme inhibitorsspongesbacteria |
| spellingShingle | Nadia Ruocco Susan Costantini Flora Palumbo Maria Costantini Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications Marine Drugs enzyme inhibitors sponges bacteria |
| title | Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications |
| title_full | Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications |
| title_fullStr | Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications |
| title_full_unstemmed | Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications |
| title_short | Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications |
| title_sort | marine sponges and bacteria as challenging sources of enzyme inhibitors for pharmacological applications |
| topic | enzyme inhibitors sponges bacteria |
| url | http://www.mdpi.com/1660-3397/15/6/173 |
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