The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling.

The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling.

The adjuvanticity of bacterial adenylate cyclase toxins has been ascribed to their capacity, largely mediated by cAMP, to modulate APC activation, resulting in the expression of Th2-driving cytokines. On the other hand, cAMP has been demonstrated to induce a Th2 bias when present during T cell primi...

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Bibliographic Details
Main Authors: Silvia Rossi Paccani, Marisa Benagiano, Nagaja Capitani, Irene Zornetta, Daniel Ladant, Cesare Montecucco, Mario M D'Elios, Cosima T Baldari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-03-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19266022/?tool=EBI

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