Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of <i>Neocryptodiscus papillaris</i> with Cytotoxic Activity on Renal Cancer Cells
Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of <i>Neocryptodiscus papillaris</i> based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells. While the major prenylated furanocoumarin derivat...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/13/3040 |
| _version_ | 1797563397596774400 |
|---|---|
| author | Fatma Tosun Feyyaz Mıhoğlugil John A. A. Beutler Esra Eroğlu Özkan Mahmut Miski |
| author_facet | Fatma Tosun Feyyaz Mıhoğlugil John A. A. Beutler Esra Eroğlu Özkan Mahmut Miski |
| author_sort | Fatma Tosun |
| collection | DOAJ |
| description | Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of <i>Neocryptodiscus papillaris</i> based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells. While the major prenylated furanocoumarin derivatives and osthol isolated from the dichloromethane extract were responsible for the activity in the colon and breast cancer cell lines, the 4′-acylated osthol derivatives including a novel coumarino-alkaloid; neopapillarine) demonstrated selective cytotoxic activity in A498 and UO31 renal cancer cell lines. |
| first_indexed | 2024-03-10T18:43:06Z |
| format | Article |
| id | doaj.art-ef58f374f51b43dc801d4adb211840cc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:43:06Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ef58f374f51b43dc801d4adb211840cc2023-11-20T05:46:04ZengMDPI AGMolecules1420-30492020-07-012513304010.3390/molecules25133040Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of <i>Neocryptodiscus papillaris</i> with Cytotoxic Activity on Renal Cancer CellsFatma Tosun0Feyyaz Mıhoğlugil1John A. A. Beutler2Esra Eroğlu Özkan3Mahmut Miski4School of Pharmacy, Department of Pharmacognosy, Istanbul Medipol University, 34810 Istanbul, TurkeyFaculty of Pharmacy, Department of Pharmacognosy, Cyprus International University, 99258 Nicosia, Northern CyprusMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USAMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USAFaculty of Pharmacy, Department of Pharmacognosy, Istanbul University, 34116 Istanbul, TurkeySeveral simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of <i>Neocryptodiscus papillaris</i> based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells. While the major prenylated furanocoumarin derivatives and osthol isolated from the dichloromethane extract were responsible for the activity in the colon and breast cancer cell lines, the 4′-acylated osthol derivatives including a novel coumarino-alkaloid; neopapillarine) demonstrated selective cytotoxic activity in A498 and UO31 renal cancer cell lines.https://www.mdpi.com/1420-3049/25/13/3040neocryptodiscus papillarisapiaceaesimple coumarinsfuranocoumarinsprenylated coumarinscoumarino-alkaloid |
| spellingShingle | Fatma Tosun Feyyaz Mıhoğlugil John A. A. Beutler Esra Eroğlu Özkan Mahmut Miski Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of <i>Neocryptodiscus papillaris</i> with Cytotoxic Activity on Renal Cancer Cells Molecules neocryptodiscus papillaris apiaceae simple coumarins furanocoumarins prenylated coumarins coumarino-alkaloid |
| title | Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of <i>Neocryptodiscus papillaris</i> with Cytotoxic Activity on Renal Cancer Cells |
| title_full | Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of <i>Neocryptodiscus papillaris</i> with Cytotoxic Activity on Renal Cancer Cells |
| title_fullStr | Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of <i>Neocryptodiscus papillaris</i> with Cytotoxic Activity on Renal Cancer Cells |
| title_full_unstemmed | Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of <i>Neocryptodiscus papillaris</i> with Cytotoxic Activity on Renal Cancer Cells |
| title_short | Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of <i>Neocryptodiscus papillaris</i> with Cytotoxic Activity on Renal Cancer Cells |
| title_sort | neopapillarine an unusual coumarino alkaloid from the root extract of i neocryptodiscus papillaris i with cytotoxic activity on renal cancer cells |
| topic | neocryptodiscus papillaris apiaceae simple coumarins furanocoumarins prenylated coumarins coumarino-alkaloid |
| url | https://www.mdpi.com/1420-3049/25/13/3040 |
| work_keys_str_mv | AT fatmatosun neopapillarineanunusualcoumarinoalkaloidfromtherootextractofineocryptodiscuspapillarisiwithcytotoxicactivityonrenalcancercells AT feyyazmıhoglugil neopapillarineanunusualcoumarinoalkaloidfromtherootextractofineocryptodiscuspapillarisiwithcytotoxicactivityonrenalcancercells AT johnaabeutler neopapillarineanunusualcoumarinoalkaloidfromtherootextractofineocryptodiscuspapillarisiwithcytotoxicactivityonrenalcancercells AT esraerogluozkan neopapillarineanunusualcoumarinoalkaloidfromtherootextractofineocryptodiscuspapillarisiwithcytotoxicactivityonrenalcancercells AT mahmutmiski neopapillarineanunusualcoumarinoalkaloidfromtherootextractofineocryptodiscuspapillarisiwithcytotoxicactivityonrenalcancercells |