PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.

PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.

PERK (EIF2AK3) is an ER-resident eIF2α kinase required for memory flexibility and metabotropic glutamate receptor-dependent long-term depression, processes known to be dependent on new protein synthesis. Here we investigated PERK's role in working memory, a cognitive ability that is independent...

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Bibliographic Details
Main Authors: Siying Zhu, Keely Henninger, Barbara C McGrath, Douglas R Cavener
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5023101?pdf=render

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