Pancreatic carcinoma development: new etiological and pathogenetic evidence
Pancreatic adenocarcinoma (PAC) is a very aggressive cancer with a poor prognosis. To date, the causes and pathogenetic mechanisms involved in the development of this malignancy remain largely unknown. Therefore, additional studies are required to improve our knowledge of the events that occur durin...
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Format: | Article |
Language: | English |
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PAGEPress Publications
2013-12-01
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Series: | Italian Journal of Medicine |
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Online Access: | http://www.italjmed.org/index.php/ijm/article/view/96 |
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author | Sirio Fiorino Letizia Bacchi-Reggiani Laura Pontoriero Claudio Gallo Elisabetta Chili Michele Masetti Nicola Zanini Anna Grondona Tania Silvestri Gaia Deleonardi Elisabetta Magrini Roberto Motta Adele Fornelli Arrigo Bondi Dario De Biase Paola Baccarini Giovanni Tallini Antonio Tropeano Andrea Cuppini Gastone Castellani Elio Jovine |
author_facet | Sirio Fiorino Letizia Bacchi-Reggiani Laura Pontoriero Claudio Gallo Elisabetta Chili Michele Masetti Nicola Zanini Anna Grondona Tania Silvestri Gaia Deleonardi Elisabetta Magrini Roberto Motta Adele Fornelli Arrigo Bondi Dario De Biase Paola Baccarini Giovanni Tallini Antonio Tropeano Andrea Cuppini Gastone Castellani Elio Jovine |
author_sort | Sirio Fiorino |
collection | DOAJ |
description | Pancreatic adenocarcinoma (PAC) is a very aggressive cancer with a poor prognosis. To date, the causes and pathogenetic mechanisms involved in the development of this malignancy remain largely unknown. Therefore, additional studies are required to improve our knowledge of the events that occur during the process of pancreatic carcinogenesis. The purpose of this article is to describe the most recent evidence, concerning the possible risk factors and mechanisms that may contribute to determine the development of PAC, as well as models, such as the tensegrity model, that may explain this complex process. Available studies suggest that approximately 15-20% of human malignancies are somehow associated with chronic infection. Some epidemiological research has shown that some infectious agents represent risk factors for PAC. In particular, several reports showed that the infection caused by some micro-organisms, including <em>helicobacter pylori </em>and some bacterial species of oral microbiota, as well as by viral agents, such as human immunodeficiency virus (HIV), and hepatitis B (HBV) and C (HCV) viruses, is associated with an increased probability of developing PAC. For the first time, observational studies and meta-analyses have suggested that HBV and HCV, two hepatotropic viruses with oncogenic properties, may be also risk factors for PAC. However, the small number of available reports, nearly all performed in Asian populations, limits their validity to these ethnic groups. Therefore, additional studies focusing on populations of different geographical areas and enrolling larger series of patients are required to confirm this association. Furthermore, an accurate description and a better understanding of the events and of the pathogenetic mechanisms involved in the process of pancreatic carcinogenesis, as proposed by the tensegrity model, might be a useful approach to effectively deal with this pathology. |
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institution | Directory Open Access Journal |
issn | 1877-9344 1877-9352 |
language | English |
last_indexed | 2024-03-09T09:32:28Z |
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series | Italian Journal of Medicine |
spelling | doaj.art-ef59710c0eab41a8a59c7bcc44dfc8fb2023-12-02T03:29:01ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522013-12-017424225210.4081/itjm.2013.242368Pancreatic carcinoma development: new etiological and pathogenetic evidenceSirio Fiorino0Letizia Bacchi-Reggiani1Laura Pontoriero2Claudio Gallo3Elisabetta Chili4Michele Masetti5Nicola Zanini6Anna Grondona7Tania Silvestri8Gaia Deleonardi9Elisabetta Magrini10Roberto Motta11Adele Fornelli12Arrigo Bondi13Dario De Biase14Paola Baccarini15Giovanni Tallini16Antonio Tropeano17Andrea Cuppini18Gastone Castellani19Elio Jovine20UO di Medicina Interna, Ospedale di Budrio, Budrio (BO)Istituto di Cardiologia, Policlinico S. Orsola Malpighi, Università degli Studi di BolognaUO Materno Infantile, Distretto Lametino, ASP, CatanzaroMedico Specialista in Malattie InfettiveUO di Anestesia e Rianimazione, Azienda Ospedaliera-Universitaria, Policlinico di Modena, ModenaUO di Chirurgia A, Ospedale Maggiore, BolognaUO di Chirurgia A, Ospedale Maggiore, BolognaLaboratorio Centralizzato, Ospedale Maggiore, BolognaLaboratorio Centralizzato, Ospedale Maggiore, BolognaLaboratorio Centralizzato, Ospedale Maggiore, BolognaLaboratorio Centralizzato, Ospedale Maggiore, BolognaLaboratorio Centralizzato, Ospedale Maggiore, BolognaServizio di Anatomia Patologica, Ospedale Maggiore, BolognaServizio di Anatomia Patologica, Ospedale Maggiore, BolognaServizio di Anatomia Patologica, Ospedale Bellaria, BolognaServizio di Anatomia Patologica, Ospedale Bellaria, BolognaServizio di Anatomia Patologica, Ospedale Bellaria, BolognaSpecialista in OdontoiatriaUO di Medicina Interna, Ospedale di Budrio, Budrio (BO)Istituto di Fisica, Università degli Studi di BolognaUO di Chirurgia A, Ospedale Maggiore, BolognaPancreatic adenocarcinoma (PAC) is a very aggressive cancer with a poor prognosis. To date, the causes and pathogenetic mechanisms involved in the development of this malignancy remain largely unknown. Therefore, additional studies are required to improve our knowledge of the events that occur during the process of pancreatic carcinogenesis. The purpose of this article is to describe the most recent evidence, concerning the possible risk factors and mechanisms that may contribute to determine the development of PAC, as well as models, such as the tensegrity model, that may explain this complex process. Available studies suggest that approximately 15-20% of human malignancies are somehow associated with chronic infection. Some epidemiological research has shown that some infectious agents represent risk factors for PAC. In particular, several reports showed that the infection caused by some micro-organisms, including <em>helicobacter pylori </em>and some bacterial species of oral microbiota, as well as by viral agents, such as human immunodeficiency virus (HIV), and hepatitis B (HBV) and C (HCV) viruses, is associated with an increased probability of developing PAC. For the first time, observational studies and meta-analyses have suggested that HBV and HCV, two hepatotropic viruses with oncogenic properties, may be also risk factors for PAC. However, the small number of available reports, nearly all performed in Asian populations, limits their validity to these ethnic groups. Therefore, additional studies focusing on populations of different geographical areas and enrolling larger series of patients are required to confirm this association. Furthermore, an accurate description and a better understanding of the events and of the pathogenetic mechanisms involved in the process of pancreatic carcinogenesis, as proposed by the tensegrity model, might be a useful approach to effectively deal with this pathology.http://www.italjmed.org/index.php/ijm/article/view/96pancreatic carcinoma, hepatitis B virus, hepatitis C virus, tensegrity, immune response. |
spellingShingle | Sirio Fiorino Letizia Bacchi-Reggiani Laura Pontoriero Claudio Gallo Elisabetta Chili Michele Masetti Nicola Zanini Anna Grondona Tania Silvestri Gaia Deleonardi Elisabetta Magrini Roberto Motta Adele Fornelli Arrigo Bondi Dario De Biase Paola Baccarini Giovanni Tallini Antonio Tropeano Andrea Cuppini Gastone Castellani Elio Jovine Pancreatic carcinoma development: new etiological and pathogenetic evidence Italian Journal of Medicine pancreatic carcinoma, hepatitis B virus, hepatitis C virus, tensegrity, immune response. |
title | Pancreatic carcinoma development: new etiological and pathogenetic evidence |
title_full | Pancreatic carcinoma development: new etiological and pathogenetic evidence |
title_fullStr | Pancreatic carcinoma development: new etiological and pathogenetic evidence |
title_full_unstemmed | Pancreatic carcinoma development: new etiological and pathogenetic evidence |
title_short | Pancreatic carcinoma development: new etiological and pathogenetic evidence |
title_sort | pancreatic carcinoma development new etiological and pathogenetic evidence |
topic | pancreatic carcinoma, hepatitis B virus, hepatitis C virus, tensegrity, immune response. |
url | http://www.italjmed.org/index.php/ijm/article/view/96 |
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