Adipocyte Specific HO-1 Gene Therapy Is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model

Adipocyte Specific HO-1 Gene Therapy Is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model

Obesity is a risk factor for vascular dysfunction and insulin resistance. The study aim was to demonstrate that adipocyte-specific HO-1 (heme oxygenase-1) gene therapy is a therapeutic approach for preventing the development of obesity-induced metabolic disease in an obese-mice model. Specific expre...

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Bibliographic Details
Main Authors: Shailendra P. Singh, Menachem Greenberg, Yosef Glick, Lars Bellner, Gaia Favero, Rita Rezzani, Luigi Fabrizio Rodella, Kevin Agostinucci, Joseph I. Shapiro, Nader G. Abraham
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Antioxidants
Subjects:
antioxidant
gene-ho-1
adiponectin
adipocytes
pgc1-α
hyperglycemia
hypertension
Online Access:https://www.mdpi.com/2076-3921/9/1/40

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