RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats

RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats

Background: Histone deacetylase 3 (HDAC3) restores chromatin nucleosomes to a transcriptional repression state, thereby inhibiting gene expression. Studies have found that HDAC3 expression is upregulated in a variety of pathological states of the central nervous system and related to its neurotoxici...

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Bibliographic Details
Main Authors: Hai-Ping Gu, Xiao-Feng Wu, Ya-Ting Gong, Mu-Yao Wu, Meng-Ying Shi, Ya-ming Sun, Bao-Qi Dang, Gang Chen
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Heliyon
Subjects:
Surgical brain injury
RGFP966
HDAC3
HDAC3/Nrf2 signal pathway
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023053689

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