Rap1a Regulates Cardiac Fibroblast Contraction of 3D Diabetic Collagen Matrices by Increased Activation of the AGE/RAGE Cascade

Rap1a Regulates Cardiac Fibroblast Contraction of 3D Diabetic Collagen Matrices by Increased Activation of the AGE/RAGE Cascade

Cardiovascular disease is a common diabetic complication that can arise when cardiac fibroblasts transition into myofibroblasts. Myofibroblast transition can be induced by advanced glycated end products (AGEs) present in the extracellular matrix (ECM) activating RAGE (receptor for advanced glycated...

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Bibliographic Details
Main Authors: Stephanie D. Burr, James A. Stewart
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
Rap1a
AGE/RAGE signaling
cardiac fibroblasts
collagen
3D collagen matrix
diabetes
Online Access:https://www.mdpi.com/2073-4409/10/6/1286

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