Role of antioxidants in the treatment of oral submucous fibrosis: A clinical and histopathological study
Background: With the increased incidence of oral submucous fibrosis and treatment being not completely satisfactory, the need for alternative method of treatment is increasing. The present study evaluates the efficacy of oral antioxidant preparations in the treatment of clinically and histopathologi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2009;volume=21;issue=4;spage=179;epage=183;aulast=Kumar;type=0 |
| _version_ | 1818528403047841792 |
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| author | B Vijay Kumar |
| author_facet | B Vijay Kumar |
| author_sort | B Vijay Kumar |
| collection | DOAJ |
| description | Background: With the increased incidence of oral submucous fibrosis and treatment being not completely satisfactory, the need for alternative method of treatment is increasing. The present study evaluates the efficacy of oral antioxidant preparations in the treatment of clinically and histopathologically proved oral submucous fibrosis. Methods: Study was conducted in 40 patients of two groups of all ages who were clinically and histopathologically proved with oral submucous fibrosis with standard data grading and biopsies before and after the study for evaluation. Results: On comparison with the control group of placebo treatment, antioxidant therapy has shown a significant improvement (i e 70′0 P < 0.001 for interincisal distance: P < 0.001 for tongue protrusion and P < 0.05 for blowing capacity) and moderate improvement in histopathological findings of the treatment group. Conclusions: Significant number of cases have shown increased mouth opening, tongue protrusion. and blowing capacity and decreased burning sensation after treatment with antioxidants. Histopathologically, there is a certain amount of improvement, but not proportional with clinical improvement which shows that antioxidants can be useful therapeutic adjuvants to the already available treatment modalities in oral submucous fibrosis. |
| first_indexed | 2024-12-11T06:49:19Z |
| format | Article |
| id | doaj.art-ef5d68bc4d054e68b7ff410fcb0edd41 |
| institution | Directory Open Access Journal |
| issn | 0972-1363 0975-1572 |
| language | English |
| last_indexed | 2024-12-11T06:49:19Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj.art-ef5d68bc4d054e68b7ff410fcb0edd412022-12-22T01:16:57ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13630975-15722009-01-01214179183Role of antioxidants in the treatment of oral submucous fibrosis: A clinical and histopathological studyB Vijay KumarBackground: With the increased incidence of oral submucous fibrosis and treatment being not completely satisfactory, the need for alternative method of treatment is increasing. The present study evaluates the efficacy of oral antioxidant preparations in the treatment of clinically and histopathologically proved oral submucous fibrosis. Methods: Study was conducted in 40 patients of two groups of all ages who were clinically and histopathologically proved with oral submucous fibrosis with standard data grading and biopsies before and after the study for evaluation. Results: On comparison with the control group of placebo treatment, antioxidant therapy has shown a significant improvement (i e 70′0 P < 0.001 for interincisal distance: P < 0.001 for tongue protrusion and P < 0.05 for blowing capacity) and moderate improvement in histopathological findings of the treatment group. Conclusions: Significant number of cases have shown increased mouth opening, tongue protrusion. and blowing capacity and decreased burning sensation after treatment with antioxidants. Histopathologically, there is a certain amount of improvement, but not proportional with clinical improvement which shows that antioxidants can be useful therapeutic adjuvants to the already available treatment modalities in oral submucous fibrosis.http://www.jiaomr.in/article.asp?issn=0972-1363;year=2009;volume=21;issue=4;spage=179;epage=183;aulast=Kumar;type=0Antioxidantsblowing capacityinterincisal distanceoral submucous fibrosistongue protrusion |
| spellingShingle | B Vijay Kumar Role of antioxidants in the treatment of oral submucous fibrosis: A clinical and histopathological study Journal of Indian Academy of Oral Medicine and Radiology Antioxidants blowing capacity interincisal distance oral submucous fibrosis tongue protrusion |
| title | Role of antioxidants in the treatment of oral submucous fibrosis: A clinical and histopathological study |
| title_full | Role of antioxidants in the treatment of oral submucous fibrosis: A clinical and histopathological study |
| title_fullStr | Role of antioxidants in the treatment of oral submucous fibrosis: A clinical and histopathological study |
| title_full_unstemmed | Role of antioxidants in the treatment of oral submucous fibrosis: A clinical and histopathological study |
| title_short | Role of antioxidants in the treatment of oral submucous fibrosis: A clinical and histopathological study |
| title_sort | role of antioxidants in the treatment of oral submucous fibrosis a clinical and histopathological study |
| topic | Antioxidants blowing capacity interincisal distance oral submucous fibrosis tongue protrusion |
| url | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2009;volume=21;issue=4;spage=179;epage=183;aulast=Kumar;type=0 |
| work_keys_str_mv | AT bvijaykumar roleofantioxidantsinthetreatmentoforalsubmucousfibrosisaclinicalandhistopathologicalstudy |