Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules
The importance of Xenorhabdus and Photorhabdus symbionts to their respective Steinernema and Heterorhabditis nematode hosts is that they not only contribute to their entomopathogenicity but also to their fecundity through the production of small molecules. Thus, this mini-review gives a brief introd...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.993688/full |
| _version_ | 1811261771839700992 |
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| author | Ryan Musumba Awori Ryan Musumba Awori |
| author_facet | Ryan Musumba Awori Ryan Musumba Awori |
| author_sort | Ryan Musumba Awori |
| collection | DOAJ |
| description | The importance of Xenorhabdus and Photorhabdus symbionts to their respective Steinernema and Heterorhabditis nematode hosts is that they not only contribute to their entomopathogenicity but also to their fecundity through the production of small molecules. Thus, this mini-review gives a brief introductory overview of these nematophilic bacteria. Specifically, their type species, nematode hosts, and geographic region of isolations are tabulated. The use of nucleotide sequence-based techniques for their species delineation and how pangenomes can improve this are highlighted. Using the Steinernema–Xenorhabdus association as an example, the bacterium-nematode lifecycle is visualized with an emphasis on the role of bacterial biomolecules. Those currently in drug development are discussed, and two potential antimalarial lead compounds are highlighted. Thus, this mini-review tabulates forty-eight significant nematophilic bacteria and visualizes the ecological importance of their biomolecules. It further discusses three of these biomolecules that are currently in drug development. Through it, one is introduced to Xenorhabdus and Photorhabdus bacteria, their natural production of biomolecules in the nematode-bacterium lifecycle, and how these molecules are useful in developing novel therapies. |
| first_indexed | 2024-04-12T19:11:51Z |
| format | Article |
| id | doaj.art-ef5e19da1bb044e7add2a0735d4b4cf5 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T19:11:51Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ef5e19da1bb044e7add2a0735d4b4cf52022-12-22T03:19:51ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-09-011310.3389/fmicb.2022.993688993688Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomoleculesRyan Musumba Awori0Ryan Musumba Awori1Department of Biology, University of Nairobi, Nairobi, KenyaElakistos Biosciences, Nairobi, KenyaThe importance of Xenorhabdus and Photorhabdus symbionts to their respective Steinernema and Heterorhabditis nematode hosts is that they not only contribute to their entomopathogenicity but also to their fecundity through the production of small molecules. Thus, this mini-review gives a brief introductory overview of these nematophilic bacteria. Specifically, their type species, nematode hosts, and geographic region of isolations are tabulated. The use of nucleotide sequence-based techniques for their species delineation and how pangenomes can improve this are highlighted. Using the Steinernema–Xenorhabdus association as an example, the bacterium-nematode lifecycle is visualized with an emphasis on the role of bacterial biomolecules. Those currently in drug development are discussed, and two potential antimalarial lead compounds are highlighted. Thus, this mini-review tabulates forty-eight significant nematophilic bacteria and visualizes the ecological importance of their biomolecules. It further discusses three of these biomolecules that are currently in drug development. Through it, one is introduced to Xenorhabdus and Photorhabdus bacteria, their natural production of biomolecules in the nematode-bacterium lifecycle, and how these molecules are useful in developing novel therapies.https://www.frontiersin.org/articles/10.3389/fmicb.2022.993688/fullnematophilic bacteriaXenorhabdus bacteriaPhotorhabdus bacteriaentomopathogenic nematode (EPN)natural product (NP)pangenomics |
| spellingShingle | Ryan Musumba Awori Ryan Musumba Awori Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules Frontiers in Microbiology nematophilic bacteria Xenorhabdus bacteria Photorhabdus bacteria entomopathogenic nematode (EPN) natural product (NP) pangenomics |
| title | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
| title_full | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
| title_fullStr | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
| title_full_unstemmed | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
| title_short | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
| title_sort | nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
| topic | nematophilic bacteria Xenorhabdus bacteria Photorhabdus bacteria entomopathogenic nematode (EPN) natural product (NP) pangenomics |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.993688/full |
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