Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study
Long non-coding RNAs’ HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016, and HULC rs7763881 are progressively reported having a close genetic affinity with esophageal carcinogenesis in the East. Nonetheless, their correlation with variables already endorsed as significant prognostic factors in...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/3/537 |
| _version_ | 1797319045750456320 |
|---|---|
| author | Efstratia Baili Maria Gazouli Andreas C. Lazaris Prodromos Kanavidis Maria Boura Adamantios Michalinos Alexandros Charalabopoulos Theodore Liakakos Andreas Alexandrou |
| author_facet | Efstratia Baili Maria Gazouli Andreas C. Lazaris Prodromos Kanavidis Maria Boura Adamantios Michalinos Alexandros Charalabopoulos Theodore Liakakos Andreas Alexandrou |
| author_sort | Efstratia Baili |
| collection | DOAJ |
| description | Long non-coding RNAs’ HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016, and HULC rs7763881 are progressively reported having a close genetic affinity with esophageal carcinogenesis in the East. Nonetheless, their correlation with variables already endorsed as significant prognostic factors in terms of staging, guiding treatment and predicting recurrence, metastasis, and survival have yet to be explored. Herein, we investigated their prognostic value by correlating them with clinicopathological and laboratory prognostic markers in esophageal cancer in the West. Formalin-fixed paraffin-embedded tissue specimens from 95 consecutive patients operated on for esophageal cancer between 2014 and 2018 were compared with 121 healthy community controls. HULC was not detected differently in any of the cancer prognostic subgroups. LINC00951 was underrepresented in Ca19.9 elevated subgroup. HOTAIR was more frequent in both worse differentiation grade and positive Signet-Ring-Cell and Ca19.9 subgroups. POLR2E was identified less frequently in Adenocarcinoma, Signet-Ring-Cell, and Diffuse histologies, as well as in Perineural, Lymphovascular, and Perivascular Invasion positive, while it was overrepresented in CEA positive subgroup. These lncRNAs polymorphisms may hold great potential not only as future therapeutic agents but also as novel markers for predictive analysis of esophageal cancer risk, clinical outcome, and survival. Clinical implications of these findings need to be validated with prospective larger sample-size studies. |
| first_indexed | 2024-03-08T04:00:07Z |
| format | Article |
| id | doaj.art-ef5e287165354dbe83e517181bc9f0f4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T04:00:07Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ef5e287165354dbe83e517181bc9f0f42024-02-09T15:08:56ZengMDPI AGCancers2072-66942024-01-0116353710.3390/cancers16030537Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control StudyEfstratia Baili0Maria Gazouli1Andreas C. Lazaris2Prodromos Kanavidis3Maria Boura4Adamantios Michalinos5Alexandros Charalabopoulos6Theodore Liakakos7Andreas Alexandrou8Upper Gastrointestinal and General Surgery Unit, First Department of Surgery, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, GreeceLaboratory of Biology, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, GreeceFirst Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, GreeceUpper Gastrointestinal and General Surgery Unit, First Department of Surgery, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, GreeceUpper Gastrointestinal and General Surgery Unit, First Department of Surgery, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, GreeceSchool of Medicine, European University of Cyprus, Nicosia 1516, CyprusUpper Gastrointestinal and General Surgery Unit, First Department of Surgery, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, GreeceUpper Gastrointestinal and General Surgery Unit, First Department of Surgery, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, GreeceUpper Gastrointestinal and General Surgery Unit, First Department of Surgery, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 15772 Athens, GreeceLong non-coding RNAs’ HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016, and HULC rs7763881 are progressively reported having a close genetic affinity with esophageal carcinogenesis in the East. Nonetheless, their correlation with variables already endorsed as significant prognostic factors in terms of staging, guiding treatment and predicting recurrence, metastasis, and survival have yet to be explored. Herein, we investigated their prognostic value by correlating them with clinicopathological and laboratory prognostic markers in esophageal cancer in the West. Formalin-fixed paraffin-embedded tissue specimens from 95 consecutive patients operated on for esophageal cancer between 2014 and 2018 were compared with 121 healthy community controls. HULC was not detected differently in any of the cancer prognostic subgroups. LINC00951 was underrepresented in Ca19.9 elevated subgroup. HOTAIR was more frequent in both worse differentiation grade and positive Signet-Ring-Cell and Ca19.9 subgroups. POLR2E was identified less frequently in Adenocarcinoma, Signet-Ring-Cell, and Diffuse histologies, as well as in Perineural, Lymphovascular, and Perivascular Invasion positive, while it was overrepresented in CEA positive subgroup. These lncRNAs polymorphisms may hold great potential not only as future therapeutic agents but also as novel markers for predictive analysis of esophageal cancer risk, clinical outcome, and survival. Clinical implications of these findings need to be validated with prospective larger sample-size studies.https://www.mdpi.com/2072-6694/16/3/537Single-Nucleotide-Polymorphisms (SNPs)esophageal canceresophagogastric junction carcinomalncRNAsHOTAIR rs920778LINC00951 rs11752942 |
| spellingShingle | Efstratia Baili Maria Gazouli Andreas C. Lazaris Prodromos Kanavidis Maria Boura Adamantios Michalinos Alexandros Charalabopoulos Theodore Liakakos Andreas Alexandrou Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study Cancers Single-Nucleotide-Polymorphisms (SNPs) esophageal cancer esophagogastric junction carcinoma lncRNAs HOTAIR rs920778 LINC00951 rs11752942 |
| title | Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study |
| title_full | Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study |
| title_fullStr | Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study |
| title_full_unstemmed | Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study |
| title_short | Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study |
| title_sort | genetic impact of hotair linc00951 polr2e and hulc polymorphisms in histopathological and laboratory prognostic factors in esophageal cancer in the west a case control study |
| topic | Single-Nucleotide-Polymorphisms (SNPs) esophageal cancer esophagogastric junction carcinoma lncRNAs HOTAIR rs920778 LINC00951 rs11752942 |
| url | https://www.mdpi.com/2072-6694/16/3/537 |
| work_keys_str_mv | AT efstratiabaili geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy AT mariagazouli geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy AT andreasclazaris geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy AT prodromoskanavidis geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy AT mariaboura geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy AT adamantiosmichalinos geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy AT alexandroscharalabopoulos geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy AT theodoreliakakos geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy AT andreasalexandrou geneticimpactofhotairlinc00951polr2eandhulcpolymorphismsinhistopathologicalandlaboratoryprognosticfactorsinesophagealcancerinthewestacasecontrolstudy |