Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan

Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan

Proteoglycans form a heterogeneous family of proteins with covalently bound sulfated glycosaminoglycans. The extracellular matrix proteoglycan perlecan has been proposed to bind to the platelet- and megakaryocyte-specific receptor G6bB, co-regulating platelet glycoprotein VI (GPVI) signaling. The de...

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Bibliographic Details
Main Authors:	Isabella Provenzale, Ilaria De Simone, Jonathan M. Gibbins, Johan W. M. Heemskerk, Paola E. J. van der Meijden, Chris I. Jones
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Series:	International Journal of Molecular Sciences
Subjects:	collagen-related peptide endorepellin glycoprotein VI perlecan platelet spreading proteoglycan
Online Access:	https://www.mdpi.com/1422-0067/24/17/13352

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