Lactobacillus paracasei BD5115-Derived 2-Hydroxy-3-Methylbutyric Acid Promotes Intestinal Epithelial Cells Proliferation by Upregulating the MYC Signaling Pathway

Lactobacillus paracasei BD5115-Derived 2-Hydroxy-3-Methylbutyric Acid Promotes Intestinal Epithelial Cells Proliferation by Upregulating the MYC Signaling Pathway

Metabolites of probiotics that are beneficial to human health have been isolated from the intestinal tract and natural dairy products. However, many studies on probiotics and prebiotics are limited to the observation of human cohorts and animal phenotypes. The molecular mechanisms by which metabolit...

Full description

Bibliographic Details
Main Authors:	Zhenyi Qiao, Xiaohua Wang, Chaoyue Wang, Jin Han, Weiwei Qi, Huanchang Zhang, Zhenmin Liu, Chunping You
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Nutrition
Subjects:	2-hydroxy-3-methylbutyric acid transcription factor colitis-associated cancer (CAC) Lactobacillus paracasei BD5115 intestinal epithelial cells proliferation
Online Access:	https://www.frontiersin.org/articles/10.3389/fnut.2022.799053/full

Similar Items

β-Hydroxy-β-Methylbutyrate Supplementation Promotes Antitumor Immunity in an Obesity Responsive Mouse Model of Pancreatic Ductal Adenocarcinoma
by: Michael F. Coleman, et al.
Published: (2021-12-01)

β-Hydroxy-β-methylbutyrate (HMB) supplementation in prevention and treatment of elderly sarcopenia.
by: Dominika Cieślak, et al.
Published: (2018-09-01)

β-Hydroxy-β-methylbutyrate (HMB) supplementation in prevention and treatment of elderly sarcopenia.
by: Dominika Cieślak, et al.
Published: (2018-09-01)

The Effects of 12-Week Beta-Hydroxy-Beta-Methylbutyrate Supplementation in Patients with Liver Cirrhosis: Results from a Randomized Controlled Single-Blind Pilot Study
by: Barbara Lattanzi, et al.
Published: (2021-07-01)

Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults
by: Hidehiko Nakano, et al.
Published: (2021-03-01)

The impact of acute beta-hydroxy-beta-methylbutyrate (HMB) ingestion on glucose and insulin kinetics in young and older men
by: Philip J.J. Herrod, et al.
Published: (2020-10-01)

The effects of preoperative supplementation with a combination of beta‐hydroxy‐beta‐methylbutyrate, arginine, and glutamine on inflammatory and hematological markers of patients with heart surgery: a randomized controlled trial
by: Mona Norouzi, et al.
Published: (2022-02-01)

Different effects of dietary β-hydroxy-β-methylbutyrate on composition of fatty acid and free amino acid, and fatty metabolism in the different muscles of broilers
by: Mengliao Wan, et al.
Published: (2023-10-01)

Effect of short-term beta-hydroxy-beta-methylbutyrate (HMB) supplementation on serum cortisol and testosterone levels in male wrestlers following an exhaustive exercise
by: Davoud Tavangar, et al.
Published: (2020-12-01)

β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Prevents Bone Loss during Pregnancy—Novel Evidence from a Spiny Mouse (<i>Acomys cahirinus</i>) Model
by: Ewa Tomaszewska, et al.
Published: (2021-03-01)

The influence of dietary supplementation with the leucine metabolite β-hydroxy-β-methylbutyrate (HMB) on the chemotaxis, phagocytosis and respiratory burst of peripheral blood granulocytes and monocytes in calves
by: Roman Wójcik, et al.
Published: (2020-06-01)

Association between endogenous plasma beta‐hydroxy‐beta‐methylbutyrate levels and frailty in community‐dwelling older people
by: Begoña Molina‐Baena, et al.
Published: (2024-02-01)

β-Hydroxy β-methylbutyrate (HMB) supplementation during pregnancy and perinatal period in animals studies and possible application in humans
by: Dominika Cieślak, et al.
Published: (2018-02-01)

β-Hydroxy β-methylbutyrate (HMB) supplementation during pregnancy and perinatal period in animals studies and possible application in humans
by: Dominika Cieślak, et al.
Published: (2018-02-01)

Effects of β-Hydroxy β-Methylbutyrate Supplementation on Working Memory and Hippocampal Long-Term Potentiation in Rodents
by: Alejandro Barranco, et al.
Published: (2022-03-01)

Effect of a Food for Special Medical Purposes for Muscle Recovery, Consisting of Arginine, Glutamine and Beta-Hydroxy-Beta-Methylbutyrate on Body Composition and Skin Health in Overweight and Obese Class I Sedentary Postmenopausal Women
by: Mariangela Rondanelli, et al.
Published: (2021-03-01)

Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring
by: Anna S. Clarke, et al.
Published: (2023-10-01)

Effects of combined maternal administration with alpha-ketoglutarate (AKG) and <it>β</it>-hydroxy-<it>β</it>-methylbutyrate (HMB) on prenatal programming of skeletal properties in the offspring
by: Tatara Marcin R, et al.
Published: (2012-05-01)

Produced β-hydroxybutyrate after β-hydroxy-β-methylbutyrate (HMB) administration may contribute HMB function in mice
by: Kazuki Ikeda, et al.
Published: (2021-09-01)

Evaluation of the recovery after heart surgery following preoperative supplementation with a combination of beta-hydroxy-beta-methylbutyrate, l-arginine, and l-glutamine: a double-blind randomized placebo-controlled clinical trial
by: Mona Norouzi, et al.
Published: (2022-08-01)

Effect of Resistance Training Combined with Beta‐Hydroxy‐Beta‐Methylbutyric Acid Supplements in Elderly Patients with Sarcopenia after Hip Replacement
by: Zhe Han, et al.
Published: (2022-04-01)

The Effects of Prenatal Supplementation with β-Hydroxy-β-Methylbutyrate and/or Alpha-Ketoglutaric Acid on the Development and Maturation of Mink Intestines Are Dependent on the Number of Pregnancies and the Sex of the Offspring
by: Piotr Dobrowolski, et al.
Published: (2021-05-01)

Femoral µCT Analysis, Mechanical Testing and Immunolocalization of Bone Proteins in β-Hydroxy β-Methylbutyrate (HMB) Supplemented Spiny Mouse in a Model of Pregnancy and Lactation-Associated Osteoporosis
by: Ewa Tomaszewska, et al.
Published: (2021-10-01)

Effect on an Oral Nutritional Supplement with β-Hydroxy-β-methylbutyrate and Vitamin D on Morphofunctional Aspects, Body Composition, and Phase Angle in Malnourished Patients
by: Isabel Cornejo-Pareja, et al.
Published: (2021-12-01)

Effects of Dietary Inclusion of β-Hydroxy-β-Methylbutyrate on Growth Performance, Fat Deposition, Bile Acid Metabolism, and Gut Microbiota Function in High-Fat and High-Cholesterol Diet-Challenged Layer Chickens
by: Qichao Liao, et al.
Published: (2022-07-01)

A randomized controlled trial to determine whether beta-hydroxy-beta-methylbutyrate and/or eicosapentaenoic acid improves diaphragm and quadriceps strength in critically Ill mechanically ventilated patients
by: Gerald S. Supinski, et al.
Published: (2021-08-01)

Fourier Transform Infrared Microspectroscopy Combined with Principal Component Analysis and Artificial Neural Networks for the Study of the Effect of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation on Articular Cartilage
by: Izabela Świetlicka, et al.
Published: (2021-08-01)

Single-Cell Transcriptomics Reveals That Metabolites Produced by Paenibacillus bovis sp. nov. BD3526 Ameliorate Type 2 Diabetes in GK Rats by Downregulating the Inflammatory Response
by: Zhenyi Qiao, et al.
Published: (2020-12-01)

Effects of Co-Ingestion of β-Hydroxy-β-Methylbutyrate and L-Arginine α-Ketoglutarate on Jump Performance in Young Track and Field Athletes
by: Piotr Kaczka, et al.
Published: (2021-03-01)

Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats
by: Wilson Jacob M, et al.
Published: (2012-04-01)

Genotoxicity evaluation of magnesium salts of isobutyrate and 2-methylbutyrate
by: Laurie C. Dolan, et al.
Published: (2021-01-01)

Physicochemical and Anti-UVB-Induced Skin Inflammatory Properties of <i>Lacticaseibacillus paracasei</i> Subsp. <i>paracasei</i> SS-01 Strain Exopolysaccharide
by: Yanfeng Su, et al.
Published: (2022-04-01)

A Proton-Coupled Transport System for β-Hydroxy-β-Methylbutyrate (HMB) in Blood–Brain Barrier Endothelial Cell Line hCMEC/D3
by: Kei Higuchi, et al.
Published: (2021-09-01)

Fermentation Products of Paenibacillus bovis sp. nov. BD3526 Alleviates the Symptoms of Type 2 Diabetes Mellitus in GK Rats
by: Zhenyi Qiao, et al.
Published: (2019-01-01)

Lactobacillus paracasei subsp. paracasei NTU 101 lyophilized powder improves loperamide-induced constipation in rats
by: Chien-Li Chen, et al.
Published: (2020-04-01)

BD (dé)coloniale
by: Sujarei Tali

Advances in nutritional supplementation for sarcopenia management
by: Simin Liu, et al.
Published: (2023-07-01)

Sarcopenia in the elderly: from clinical aspects to therapeutic options
by: Angelo Bianchetti, et al.
Published: (2019-04-01)

Effect of Lactobacillus paracasei probiotic in Parkinson’s male rats
by: Kimia Khandestan, et al.
Published: (2021-01-01)

The Effect Of Lactobacillus Paracasei Isolated From Yoghurt On The Growth And Production Of Staphylococcus Aureus Enterotoxin
by: Mahnoosh Parsaeimehr, et al.
Published: (2014-09-01)