Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women
Background: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. Objective: To investi...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2018-03-01
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| Series: | Iranian Journal of Immunology |
| Online Access: | https://iji.sums.ac.ir/article_39341_4a1ad39e01adb444c4e3fa0ef878e4fe.pdf |
| _version_ | 1811271514352254976 |
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| author | Narges Roomandeh AboTaleb Saremi Javad Arasteh Fatemeh Pak Majid Mirmohammadkhani Parviz Kokhaei Ahad Zare |
| author_facet | Narges Roomandeh AboTaleb Saremi Javad Arasteh Fatemeh Pak Majid Mirmohammadkhani Parviz Kokhaei Ahad Zare |
| author_sort | Narges Roomandeh |
| collection | DOAJ |
| description | Background: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. Objective: To investigate the serum concentration of regulatory and inflammatory cytokines associated with Treg and Th17 in both normal and URSA females. Methods: Forty-six women with URSA and 28 non-pregnant control women with at least one successful pregnancy were included. Serum was obtained from both groups and stored at -70°C. The serum concentrations of IL-17, IL-21, IL-22, IL-10, and TGF-β were quantitatively determined by ELISA. Results: The levels of IL-17, IL-21, and IL-22 in sera were significantly higher (P<0.001, P=0.01 and P<0.001, respectively) and TGF-β serum concentration was significantly lower (P=0.02) in URSA women compared with normal controls. Conclusion: Our results suggest that enhancement in Th17-associated cytokine levels and reduction in TGF-β may be one of the factors involved in URSA. |
| first_indexed | 2024-04-12T22:22:22Z |
| format | Article |
| id | doaj.art-ef62b8ad61be42db98d1d81e9c1a2f0a |
| institution | Directory Open Access Journal |
| issn | 1735-1383 1735-367X |
| language | English |
| last_indexed | 2024-04-12T22:22:22Z |
| publishDate | 2018-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Immunology |
| spelling | doaj.art-ef62b8ad61be42db98d1d81e9c1a2f0a2022-12-22T03:14:19ZengShiraz University of Medical SciencesIranian Journal of Immunology1735-13831735-367X2018-03-01151596739341Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile WomenNarges Roomandeh0AboTaleb Saremi1Javad Arasteh2Fatemeh Pak3Majid Mirmohammadkhani4Parviz Kokhaei5Ahad Zare6Student Research Committee and Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan,Sarem Fertility and Infertility Research Center (SAFIR) and Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, IranDepartment of Biology, Faculty of Basic Sciences, Islamic Azad University Central Tehran Branch, Tehran,Cancer Research Center and Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran,Research Center for Social Determinants of Health, Semnan University of Medical Sciences, Semnan, IranCancer Research Center and Department of Immunology, Faculty of MedicineSarem Fertility and Infertility Research Center (SAFIR) and Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, IranBackground: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. Objective: To investigate the serum concentration of regulatory and inflammatory cytokines associated with Treg and Th17 in both normal and URSA females. Methods: Forty-six women with URSA and 28 non-pregnant control women with at least one successful pregnancy were included. Serum was obtained from both groups and stored at -70°C. The serum concentrations of IL-17, IL-21, IL-22, IL-10, and TGF-β were quantitatively determined by ELISA. Results: The levels of IL-17, IL-21, and IL-22 in sera were significantly higher (P<0.001, P=0.01 and P<0.001, respectively) and TGF-β serum concentration was significantly lower (P=0.02) in URSA women compared with normal controls. Conclusion: Our results suggest that enhancement in Th17-associated cytokine levels and reduction in TGF-β may be one of the factors involved in URSA.https://iji.sums.ac.ir/article_39341_4a1ad39e01adb444c4e3fa0ef878e4fe.pdf |
| spellingShingle | Narges Roomandeh AboTaleb Saremi Javad Arasteh Fatemeh Pak Majid Mirmohammadkhani Parviz Kokhaei Ahad Zare Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women Iranian Journal of Immunology |
| title | Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women |
| title_full | Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women |
| title_fullStr | Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women |
| title_full_unstemmed | Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women |
| title_short | Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women |
| title_sort | comparing serum levels of th17 and treg cytokines in women with unexplained recurrent spontaneous abortion and fertile women |
| url | https://iji.sums.ac.ir/article_39341_4a1ad39e01adb444c4e3fa0ef878e4fe.pdf |
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