The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population
PURPOSE Although attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen psychiatric disorders in childhood, its etiology and pathophysiology are not fully elucidated. The aim of the present study was to investigate the association between ADHD and RELN gene in Turkish chi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AVES
2018-10-01
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| Series: | Psychiatry and Clinical Psychopharmacology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/24750573.2018.1478192 |
| _version_ | 1797912333072203776 |
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| author | Bilge Kara Nilfer Sahin Murat Kara Esin Sakalli Cetin Hatice Topal |
| author_facet | Bilge Kara Nilfer Sahin Murat Kara Esin Sakalli Cetin Hatice Topal |
| author_sort | Bilge Kara |
| collection | DOAJ |
| description | PURPOSE Although attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen psychiatric disorders in childhood, its etiology and pathophysiology are not fully elucidated. The aim of the present study was to investigate the association between ADHD and RELN gene in Turkish children. METHOD DNA samples were harvested from 102 patients with ADHD and 94 healthy controls. Three single-nucleotide polymorphisms of reelin gene (rs1270519, rs362691, and rs734147) were genotyped using real-time polymerase chain reaction. RESULTS A significant difference was detected between ADHD and control groups regarding rs1270519 polymorphism while no significant difference was detected between the groups regarding reelin rs362691 and rs734147 polymorphisms. CONCLUSION It was found that reelin rs12705169 gene polymorphism could play a role in ADHD etiology, indicating the need for further studies to investigate the relationship between ADHD and reelin gene polymorphism. |
| first_indexed | 2024-04-10T11:54:20Z |
| format | Article |
| id | doaj.art-ef6333d4ab2c46b781c3851a399aca83 |
| institution | Directory Open Access Journal |
| issn | 2475-0573 2475-0581 |
| language | English |
| last_indexed | 2024-04-10T11:54:20Z |
| publishDate | 2018-10-01 |
| publisher | AVES |
| record_format | Article |
| series | Psychiatry and Clinical Psychopharmacology |
| spelling | doaj.art-ef6333d4ab2c46b781c3851a399aca832023-02-15T16:17:00ZengAVESPsychiatry and Clinical Psychopharmacology2475-05732475-05812018-10-0128442342810.1080/24750573.2018.14781921478192The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish populationBilge Kara0Nilfer Sahin1Murat Kara2Esin Sakalli Cetin3Hatice Topal4Mugla Sitki Kocman UniversityMugla Sitki Kocman UniversityMugla Sitki Kocman UniversityMugla Sitki Kocman UniversityMugla Sitki Kocman UniversityPURPOSE Although attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen psychiatric disorders in childhood, its etiology and pathophysiology are not fully elucidated. The aim of the present study was to investigate the association between ADHD and RELN gene in Turkish children. METHOD DNA samples were harvested from 102 patients with ADHD and 94 healthy controls. Three single-nucleotide polymorphisms of reelin gene (rs1270519, rs362691, and rs734147) were genotyped using real-time polymerase chain reaction. RESULTS A significant difference was detected between ADHD and control groups regarding rs1270519 polymorphism while no significant difference was detected between the groups regarding reelin rs362691 and rs734147 polymorphisms. CONCLUSION It was found that reelin rs12705169 gene polymorphism could play a role in ADHD etiology, indicating the need for further studies to investigate the relationship between ADHD and reelin gene polymorphism.http://dx.doi.org/10.1080/24750573.2018.1478192Attention deficit hyperactivity disorderreelinpolymorphism |
| spellingShingle | Bilge Kara Nilfer Sahin Murat Kara Esin Sakalli Cetin Hatice Topal The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population Psychiatry and Clinical Psychopharmacology Attention deficit hyperactivity disorder reelin polymorphism |
| title | The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population |
| title_full | The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population |
| title_fullStr | The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population |
| title_full_unstemmed | The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population |
| title_short | The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population |
| title_sort | relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in turkish population |
| topic | Attention deficit hyperactivity disorder reelin polymorphism |
| url | http://dx.doi.org/10.1080/24750573.2018.1478192 |
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