Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems
Poly(2-(dimethylamino)ethylmethacrylate-b-methymethacrylate) (PDMAEMA-b-PMMA) poly(2-(dimethylamino)ethylmethacrylate-b-vinylcaprolactam-b-(2-(dimethylamino)ethyl methacrylate) (PDMAEMA-b-PVCL-b-PDMAEMA) and poly(vinylcaprolactam-b-(2-(dimethylamino)ethylmethacrylate-b-vinylcaprolactam) (PVCL-b-PDMA...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2014-03-01
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| Series: | Materials Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700031&tlng=en |
| _version_ | 1818730787092037632 |
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| author | Marli L. Tebaldi Debora Abrantes Leal Sergio R. Montoro Cesar Petzhold |
| author_facet | Marli L. Tebaldi Debora Abrantes Leal Sergio R. Montoro Cesar Petzhold |
| author_sort | Marli L. Tebaldi |
| collection | DOAJ |
| description | Poly(2-(dimethylamino)ethylmethacrylate-b-methymethacrylate) (PDMAEMA-b-PMMA) poly(2-(dimethylamino)ethylmethacrylate-b-vinylcaprolactam-b-(2-(dimethylamino)ethyl methacrylate) (PDMAEMA-b-PVCL-b-PDMAEMA) and poly(vinylcaprolactam-b-(2-(dimethylamino)ethylmethacrylate-b-vinylcaprolactam) (PVCL-b-PDMAEMA-b-PVCL) block copolymers were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization, and the effect of the solution pH on the particle size was investigated. In the case of PDMAEMA-b-PMMA, PDMAEMA was first synthesized using 2-cyanoprop-2-yl dithiobenzoate (CPDB) as a chain transfer agent (CTA), which was subsequently used for the RAFT polymerization of MMA. The triblock copolymers were obtained using PDMAEMA or PVCL as macro-CTAs prepared using dibenzyl trithiocarbonate (DBTTC) as a bifunctional RAFT agent. The structure and formation of the copolymers was confirmed through ¹H NMR and SEC analysis. The particle size varied considerably depending on the pH of the aqueous solutions of copolymers indicating that these materials could be potential candidates for biomedical applications. |
| first_indexed | 2024-12-17T23:07:20Z |
| format | Article |
| id | doaj.art-ef635b09b2b849c98a036e922a712ee9 |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-12-17T23:07:20Z |
| publishDate | 2014-03-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-ef635b09b2b849c98a036e922a712ee92022-12-21T21:29:13ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392014-03-0117suppl 119119610.1590/S1516-14392014005000033Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systemsMarli L. Tebaldi0Debora Abrantes Leal1Sergio R. Montoro2Cesar Petzhold3Universidade Federal de ItajubáUniversidade Federal de ItajubáUniversidade de São PauloFederal University of Rio Grande do SulPoly(2-(dimethylamino)ethylmethacrylate-b-methymethacrylate) (PDMAEMA-b-PMMA) poly(2-(dimethylamino)ethylmethacrylate-b-vinylcaprolactam-b-(2-(dimethylamino)ethyl methacrylate) (PDMAEMA-b-PVCL-b-PDMAEMA) and poly(vinylcaprolactam-b-(2-(dimethylamino)ethylmethacrylate-b-vinylcaprolactam) (PVCL-b-PDMAEMA-b-PVCL) block copolymers were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization, and the effect of the solution pH on the particle size was investigated. In the case of PDMAEMA-b-PMMA, PDMAEMA was first synthesized using 2-cyanoprop-2-yl dithiobenzoate (CPDB) as a chain transfer agent (CTA), which was subsequently used for the RAFT polymerization of MMA. The triblock copolymers were obtained using PDMAEMA or PVCL as macro-CTAs prepared using dibenzyl trithiocarbonate (DBTTC) as a bifunctional RAFT agent. The structure and formation of the copolymers was confirmed through ¹H NMR and SEC analysis. The particle size varied considerably depending on the pH of the aqueous solutions of copolymers indicating that these materials could be potential candidates for biomedical applications.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700031&tlng=enpoly(dimethylaminoethyl methacrylate)reversible addition-fragmentation chain transfer (RAFT) polymerizationpoly(methylmethacrylate)poly(vinylcaprolactam) |
| spellingShingle | Marli L. Tebaldi Debora Abrantes Leal Sergio R. Montoro Cesar Petzhold Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems Materials Research poly(dimethylaminoethyl methacrylate) reversible addition-fragmentation chain transfer (RAFT) polymerization poly(methylmethacrylate) poly(vinylcaprolactam) |
| title | Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems |
| title_full | Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems |
| title_fullStr | Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems |
| title_full_unstemmed | Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems |
| title_short | Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems |
| title_sort | synthesis of stimuli sensitive copolymers by raft polymerization potential candidates as drug delivery systems |
| topic | poly(dimethylaminoethyl methacrylate) reversible addition-fragmentation chain transfer (RAFT) polymerization poly(methylmethacrylate) poly(vinylcaprolactam) |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700031&tlng=en |
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