SARS-CoV-2 Impact on Red Blood Cell Morphology
Severe COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety of ways. To date, however, the vast majority of research has been devoted to the study of leukocytes, while erythrocyte morphological changes have received significantly less attention. The aim...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/11/2902 |
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| author | Kirill A. Kondratov Alexander A. Artamonov Vladimir Yu. Mikhailovskii Anastasiya A. Velmiskina Sergey V. Mosenko Evgeniy A. Grigoryev Anna Yu. Anisenkova Yuri V. Nikitin Svetlana V. Apalko Natalya N. Sushentseva Andrey M. Ivanov Sergey G. Scherbak |
| author_facet | Kirill A. Kondratov Alexander A. Artamonov Vladimir Yu. Mikhailovskii Anastasiya A. Velmiskina Sergey V. Mosenko Evgeniy A. Grigoryev Anna Yu. Anisenkova Yuri V. Nikitin Svetlana V. Apalko Natalya N. Sushentseva Andrey M. Ivanov Sergey G. Scherbak |
| author_sort | Kirill A. Kondratov |
| collection | DOAJ |
| description | Severe COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety of ways. To date, however, the vast majority of research has been devoted to the study of leukocytes, while erythrocyte morphological changes have received significantly less attention. The aim of this research was to identify erythrocyte morphology abnormalities that occur in COVID-19, compare the number of different poikilocyte types, and measure erythrocyte sizes to provide data on size dispersion. Red blood cells obtained from 6 control donors (800–2200 cells per donor) and 5 COVID-19 patients (800–1900 cells per patient) were examined using low-voltage scanning electron microscopy. We did not discover any forms of erythrocyte morphology abnormalities that would be specific to COVID-19. Among COVID-19 patients, we observed an increase in the number of acanthocytes (<i>p</i> = 0.01) and a decrease in the number of spherocytes (<i>p</i> = 0.03). In addition, our research demonstrates that COVID-19 causes an increase in the median (<i>p</i> = 0.004) and interquartile range (<i>p</i> = 0.009) when assessing erythrocyte size. The limitation of our study is a small number of participants. |
| first_indexed | 2024-03-09T17:01:05Z |
| format | Article |
| id | doaj.art-ef64fe95c1a9412f8fab166f15910b6d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:01:05Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ef64fe95c1a9412f8fab166f15910b6d2023-11-24T14:30:38ZengMDPI AGBiomedicines2227-90592023-10-011111290210.3390/biomedicines11112902SARS-CoV-2 Impact on Red Blood Cell MorphologyKirill A. Kondratov0Alexander A. Artamonov1Vladimir Yu. Mikhailovskii2Anastasiya A. Velmiskina3Sergey V. Mosenko4Evgeniy A. Grigoryev5Anna Yu. Anisenkova6Yuri V. Nikitin7Svetlana V. Apalko8Natalya N. Sushentseva9Andrey M. Ivanov10Sergey G. Scherbak11City Hospital No. 40, St. Petersburg 197706, RussiaS. M. Kirov Military Medical Academy, St. Petersburg 194044, RussiaSaint-Petersburg State University, St. Petersburg 199034, RussiaCity Hospital No. 40, St. Petersburg 197706, RussiaCity Hospital No. 40, St. Petersburg 197706, RussiaSaint-Petersburg State University, St. Petersburg 199034, RussiaCity Hospital No. 40, St. Petersburg 197706, RussiaS. M. Kirov Military Medical Academy, St. Petersburg 194044, RussiaCity Hospital No. 40, St. Petersburg 197706, RussiaCity Hospital No. 40, St. Petersburg 197706, RussiaS. M. Kirov Military Medical Academy, St. Petersburg 194044, RussiaCity Hospital No. 40, St. Petersburg 197706, RussiaSevere COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety of ways. To date, however, the vast majority of research has been devoted to the study of leukocytes, while erythrocyte morphological changes have received significantly less attention. The aim of this research was to identify erythrocyte morphology abnormalities that occur in COVID-19, compare the number of different poikilocyte types, and measure erythrocyte sizes to provide data on size dispersion. Red blood cells obtained from 6 control donors (800–2200 cells per donor) and 5 COVID-19 patients (800–1900 cells per patient) were examined using low-voltage scanning electron microscopy. We did not discover any forms of erythrocyte morphology abnormalities that would be specific to COVID-19. Among COVID-19 patients, we observed an increase in the number of acanthocytes (<i>p</i> = 0.01) and a decrease in the number of spherocytes (<i>p</i> = 0.03). In addition, our research demonstrates that COVID-19 causes an increase in the median (<i>p</i> = 0.004) and interquartile range (<i>p</i> = 0.009) when assessing erythrocyte size. The limitation of our study is a small number of participants.https://www.mdpi.com/2227-9059/11/11/2902COVID-19erythrocytered blood cellscytokine stormsevere COVID-19low-voltage scanning electron microscopy |
| spellingShingle | Kirill A. Kondratov Alexander A. Artamonov Vladimir Yu. Mikhailovskii Anastasiya A. Velmiskina Sergey V. Mosenko Evgeniy A. Grigoryev Anna Yu. Anisenkova Yuri V. Nikitin Svetlana V. Apalko Natalya N. Sushentseva Andrey M. Ivanov Sergey G. Scherbak SARS-CoV-2 Impact on Red Blood Cell Morphology Biomedicines COVID-19 erythrocyte red blood cells cytokine storm severe COVID-19 low-voltage scanning electron microscopy |
| title | SARS-CoV-2 Impact on Red Blood Cell Morphology |
| title_full | SARS-CoV-2 Impact on Red Blood Cell Morphology |
| title_fullStr | SARS-CoV-2 Impact on Red Blood Cell Morphology |
| title_full_unstemmed | SARS-CoV-2 Impact on Red Blood Cell Morphology |
| title_short | SARS-CoV-2 Impact on Red Blood Cell Morphology |
| title_sort | sars cov 2 impact on red blood cell morphology |
| topic | COVID-19 erythrocyte red blood cells cytokine storm severe COVID-19 low-voltage scanning electron microscopy |
| url | https://www.mdpi.com/2227-9059/11/11/2902 |
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