HIF-1α participates in secondary brain injury through regulating neuroinflammation

HIF-1α participates in secondary brain injury through regulating neuroinflammation

A deeper understanding of the underlying biological mechanisms of secondary brain injury induced by traumatic brain injury (TBI) will greatly advance the development of effective treatments for patients with TBI. Hypoxia-inducible factor-1 alpha (HIF-1α) is a central regulator of cellular response t...

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Bibliographic Details
Main Authors: Xu Xiaojian, Yang Mengshi, Zhang Bin, Dong Jinqian, Zhuang Yuan, Ge Qianqian, Niu Fei, Liu Baiyun
Format: Article
Language:English
Published: De Gruyter 2023-02-01
Series:Translational Neuroscience
Subjects:
traumatic brain injury
hif-1α
hypoxia
neuroinflammation
apoptosis
innate immune
2-methoxyestradiol
secondary brain injury
gsea
controlled cortical impact
Online Access:https://doi.org/10.1515/tnsci-2022-0272

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