The role of epigenetics in Alzheimer's disease
Neurodegenerative diseases are debilitating and incurable condition resulting in the progressive degeneration of nerve cells which causes problems with movement or mental functioning. Alzheimer's disease is the most common form of dementia and an irreversible neurodegenerative disorder. The mec...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Journal of Geriatric Mental Health |
| Subjects: | |
| Online Access: | http://www.jgmh.org/article.asp?issn=2348-9995;year=2018;volume=5;issue=2;spage=94;epage=98;aulast=Sujeetha |
| _version_ | 1818670026873372672 |
|---|---|
| author | Purushothaman Sujeetha Jeenu Cheerian Preethi Basavaraju Puthamohan Vinayaga Moorthi Arumugam Vijaya Anand |
| author_facet | Purushothaman Sujeetha Jeenu Cheerian Preethi Basavaraju Puthamohan Vinayaga Moorthi Arumugam Vijaya Anand |
| author_sort | Purushothaman Sujeetha |
| collection | DOAJ |
| description | Neurodegenerative diseases are debilitating and incurable condition resulting in the progressive degeneration of nerve cells which causes problems with movement or mental functioning. Alzheimer's disease is the most common form of dementia and an irreversible neurodegenerative disorder. The mechanism of Alzheimer's disease is still unknown. The changes in the primary DNA sequence due to heritable alterations in the gene are known as epigenetics. The most studied epigenetic mechanisms are DNA methylation, histone modifications, and noncoding RNAs. Therefore, this change triggers the alterations in the transcriptional level of genes which are involved in the pathogenesis of Alzheimer's disease. Over the past decade, it is progressively clear that the epigenetic mechanisms play an important role in the pathogenesis of Alzheimer's disease. The literature search was performed on reviews addressing the topics in the databases PubMed and Google Scholar. This review focuses on the three major epigenetic mechanisms and their role in the pathogenesis of Alzheimer's disease. |
| first_indexed | 2024-12-17T07:01:34Z |
| format | Article |
| id | doaj.art-ef65b49f404c4df2a69173e0a6d7c633 |
| institution | Directory Open Access Journal |
| issn | 2348-9995 2395-3322 |
| language | English |
| last_indexed | 2024-12-17T07:01:34Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Geriatric Mental Health |
| spelling | doaj.art-ef65b49f404c4df2a69173e0a6d7c6332022-12-21T21:59:15ZengWolters Kluwer Medknow PublicationsJournal of Geriatric Mental Health2348-99952395-33222018-01-0152949810.4103/jgmh.jgmh_33_17The role of epigenetics in Alzheimer's diseasePurushothaman SujeethaJeenu CheerianPreethi BasavarajuPuthamohan Vinayaga MoorthiArumugam Vijaya AnandNeurodegenerative diseases are debilitating and incurable condition resulting in the progressive degeneration of nerve cells which causes problems with movement or mental functioning. Alzheimer's disease is the most common form of dementia and an irreversible neurodegenerative disorder. The mechanism of Alzheimer's disease is still unknown. The changes in the primary DNA sequence due to heritable alterations in the gene are known as epigenetics. The most studied epigenetic mechanisms are DNA methylation, histone modifications, and noncoding RNAs. Therefore, this change triggers the alterations in the transcriptional level of genes which are involved in the pathogenesis of Alzheimer's disease. Over the past decade, it is progressively clear that the epigenetic mechanisms play an important role in the pathogenesis of Alzheimer's disease. The literature search was performed on reviews addressing the topics in the databases PubMed and Google Scholar. This review focuses on the three major epigenetic mechanisms and their role in the pathogenesis of Alzheimer's disease.http://www.jgmh.org/article.asp?issn=2348-9995;year=2018;volume=5;issue=2;spage=94;epage=98;aulast=SujeethaAlzheimer's diseaseDNA methylationepigenetic modificationshistone modificationsnoncoding RNAs |
| spellingShingle | Purushothaman Sujeetha Jeenu Cheerian Preethi Basavaraju Puthamohan Vinayaga Moorthi Arumugam Vijaya Anand The role of epigenetics in Alzheimer's disease Journal of Geriatric Mental Health Alzheimer's disease DNA methylation epigenetic modifications histone modifications noncoding RNAs |
| title | The role of epigenetics in Alzheimer's disease |
| title_full | The role of epigenetics in Alzheimer's disease |
| title_fullStr | The role of epigenetics in Alzheimer's disease |
| title_full_unstemmed | The role of epigenetics in Alzheimer's disease |
| title_short | The role of epigenetics in Alzheimer's disease |
| title_sort | role of epigenetics in alzheimer s disease |
| topic | Alzheimer's disease DNA methylation epigenetic modifications histone modifications noncoding RNAs |
| url | http://www.jgmh.org/article.asp?issn=2348-9995;year=2018;volume=5;issue=2;spage=94;epage=98;aulast=Sujeetha |
| work_keys_str_mv | AT purushothamansujeetha theroleofepigeneticsinalzheimersdisease AT jeenucheerian theroleofepigeneticsinalzheimersdisease AT preethibasavaraju theroleofepigeneticsinalzheimersdisease AT puthamohanvinayagamoorthi theroleofepigeneticsinalzheimersdisease AT arumugamvijayaanand theroleofepigeneticsinalzheimersdisease AT purushothamansujeetha roleofepigeneticsinalzheimersdisease AT jeenucheerian roleofepigeneticsinalzheimersdisease AT preethibasavaraju roleofepigeneticsinalzheimersdisease AT puthamohanvinayagamoorthi roleofepigeneticsinalzheimersdisease AT arumugamvijayaanand roleofepigeneticsinalzheimersdisease |