Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by pancreatic β-cell destruction and considered to be correlated with oxidative stress. This study aimed to investigate the association of oxidative stress [superoxide dismutase (SOD) and malondialdehyde (MDA) levels], inflammati...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Brawijaya
2017-09-01
|
| Series: | Journal of Tropical Life Science |
| Subjects: | |
| Online Access: | http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/721 |
| _version_ | 1827612142351679488 |
|---|---|
| author | Lina Astari Haryudi Cahyono Edi Widjajanto |
| author_facet | Lina Astari Haryudi Cahyono Edi Widjajanto |
| author_sort | Lina Astari |
| collection | DOAJ |
| description | Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by pancreatic β-cell destruction and considered to be correlated with oxidative stress. This study aimed to investigate the association of oxidative stress [superoxide dismutase (SOD) and malondialdehyde (MDA) levels], inflammation [interleukin 10 (IL-10)], and glycemic control (HbA1c) in pediatric T1DM patients. This study included 25 T1DM subjects and 25 healthy control subjects and was designed as a cross- sectional study. SOD, MDA, and IL-10 levels were measured by ELISA. We obtained that that IL-10 and SOD levels were significantly decreased in the T1DM group, but MDA and HbA1c levels were significantly elevated in the T1DM group. IL-10 levels were positively correlated with SOD levels and negatively correlated with MDA and HbA1c. SOD levels were negatively correlated with HbA1c levels. MDA was positively correlated with HbA1c levels. IL-10 and SOD levels were significantly decreased, but MDA and HbA1c levels were significantly elevated in the T1DM group. |
| first_indexed | 2024-03-09T08:17:10Z |
| format | Article |
| id | doaj.art-ef678b49386f4fcfac55160c0fbdb843 |
| institution | Directory Open Access Journal |
| issn | 2087-5517 2527-4376 |
| language | English |
| last_indexed | 2024-03-09T08:17:10Z |
| publishDate | 2017-09-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Tropical Life Science |
| spelling | doaj.art-ef678b49386f4fcfac55160c0fbdb8432023-12-02T22:04:50ZengUniversity of BrawijayaJournal of Tropical Life Science2087-55172527-43762017-09-017328629210.11594/jtls.07.03.15236Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes MellitusLina Astari0Haryudi Cahyono1Edi Widjajanto2Department of Pediatric, Saiful Anwar General Hospital, Malang, Indonesia; Master Program of Biomedical Science, Medical Faculty of Brawijaya University, Malang, IndonesiaDepartment of Pediatric, Saiful Anwar General Hospital, Malang, IndonesiaDepartment of Pediatric, Saiful Anwar General Hospital, Malang, IndonesiaType 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by pancreatic β-cell destruction and considered to be correlated with oxidative stress. This study aimed to investigate the association of oxidative stress [superoxide dismutase (SOD) and malondialdehyde (MDA) levels], inflammation [interleukin 10 (IL-10)], and glycemic control (HbA1c) in pediatric T1DM patients. This study included 25 T1DM subjects and 25 healthy control subjects and was designed as a cross- sectional study. SOD, MDA, and IL-10 levels were measured by ELISA. We obtained that that IL-10 and SOD levels were significantly decreased in the T1DM group, but MDA and HbA1c levels were significantly elevated in the T1DM group. IL-10 levels were positively correlated with SOD levels and negatively correlated with MDA and HbA1c. SOD levels were negatively correlated with HbA1c levels. MDA was positively correlated with HbA1c levels. IL-10 and SOD levels were significantly decreased, but MDA and HbA1c levels were significantly elevated in the T1DM group.http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/721Type 1 diabetes mellitussuperoxide dismutasemalondialdehydeinterleukin 10HbA1c. |
| spellingShingle | Lina Astari Haryudi Cahyono Edi Widjajanto Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus Journal of Tropical Life Science Type 1 diabetes mellitus superoxide dismutase malondialdehyde interleukin 10 HbA1c. |
| title | Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus |
| title_full | Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus |
| title_fullStr | Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus |
| title_full_unstemmed | Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus |
| title_short | Correlation of Interleukin-10, Superoxide Dismutase (SOD), and Malondialdehyde (MDA) Levels with HbA1c in Pediatric Type 1 Diabetes Mellitus |
| title_sort | correlation of interleukin 10 superoxide dismutase sod and malondialdehyde mda levels with hba1c in pediatric type 1 diabetes mellitus |
| topic | Type 1 diabetes mellitus superoxide dismutase malondialdehyde interleukin 10 HbA1c. |
| url | http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/721 |
| work_keys_str_mv | AT linaastari correlationofinterleukin10superoxidedismutasesodandmalondialdehydemdalevelswithhba1cinpediatrictype1diabetesmellitus AT haryudicahyono correlationofinterleukin10superoxidedismutasesodandmalondialdehydemdalevelswithhba1cinpediatrictype1diabetesmellitus AT ediwidjajanto correlationofinterleukin10superoxidedismutasesodandmalondialdehydemdalevelswithhba1cinpediatrictype1diabetesmellitus |