The Transcriptional Regulator <i>Prdm1</i> Is Essential for the Early Development of the Sensory Whisker Follicle and Is Linked to the Beta-Catenin First Dermal Signal

The Transcriptional Regulator <i>Prdm1</i> Is Essential for the Early Development of the Sensory Whisker Follicle and Is Linked to the Beta-Catenin First Dermal Signal

<i>Prdm1</i> mutant mice are one of the rare mutant strains that do not develop whisker hair follicles while still displaying a pelage. Here, we show that <i>Prdm1</i> is expressed at the earliest stage of whisker development in clusters of mesenchymal cells before placode fo...

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Bibliographic Details
Main Authors: Pierluigi G. Manti, Fabrice Darbellay, Marion Leleu, Aisling Y. Coughlan, Bernard Moret, Julien Cuennet, Frederic Droux, Magali Stoudmann, Gian-Filippo Mancini, Agnès Hautier, Jessica Sordet-Dessimoz, Stephane D. Vincent, Giuseppe Testa, Giulio Cossu, Yann Barrandon
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomedicines
Subjects:
sensory vibrissae
barrel cortex
<i>Prdm1</i>
<i>Lef1</i>
Leaf
non-conserved enhancer
Online Access:https://www.mdpi.com/2227-9059/10/10/2647

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