Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease
Abstract Introduction Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer’s disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memory self-awareness. Methods Two hundred thirty-six cli...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Alzheimer’s Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13195-021-00856-x |
| _version_ | 1818825252988256256 |
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| author | Geoffroy Gagliardi Madeline Kuppe Cristina Lois Bernard Hanseeuw Patrizia Vannini for the Alzheimer’s Disease Neuroimaging Initiative |
| author_facet | Geoffroy Gagliardi Madeline Kuppe Cristina Lois Bernard Hanseeuw Patrizia Vannini for the Alzheimer’s Disease Neuroimaging Initiative |
| author_sort | Geoffroy Gagliardi |
| collection | DOAJ |
| description | Abstract Introduction Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer’s disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memory self-awareness. Methods Two hundred thirty-six clinically normal (N) and 102 impaired (I) participants from the ADNI cohort were included. Amyloid (global) and tau burden (in entorhinal and inferior temporal cortices) were assessed using positron emission tomography (PET). Self-awareness of memory was assessed using discrepancy indexes of subjective participant-informant ratings, as well as participant-objective scores of memory performance. Subjective and objective values were derived from the Everyday Cognition memory questionnaire and Logical Memory (delayed recall). Results Lower awareness (both methods) of memory function was associated with higher levels of pathology in the I group as compared to N. There was a significant effect of tauopathy, but not amyloidosis, on individual complaint, such that higher levels of tau associated with lower awareness. Discussion Impaired self-awareness appears progressively in the evolution of the disease related to AD biomarkers. Discordant subjective and objective measures may be important for clinical consideration. |
| first_indexed | 2024-12-19T00:08:49Z |
| format | Article |
| id | doaj.art-ef6b376dd87d41fca42bab9e594fadc3 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-12-19T00:08:49Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-ef6b376dd87d41fca42bab9e594fadc32022-12-21T20:46:05ZengBMCAlzheimer’s Research & Therapy1758-91932021-06-0113111110.1186/s13195-021-00856-xPathological correlates of impaired self-awareness of memory function in Alzheimer’s diseaseGeoffroy Gagliardi0Madeline Kuppe1Cristina Lois2Bernard Hanseeuw3Patrizia Vannini4for the Alzheimer’s Disease Neuroimaging InitiativeBrigham and Women’s HospitalMassachusetts General HospitalMassachusetts General HospitalMassachusetts General HospitalBrigham and Women’s HospitalAbstract Introduction Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer’s disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memory self-awareness. Methods Two hundred thirty-six clinically normal (N) and 102 impaired (I) participants from the ADNI cohort were included. Amyloid (global) and tau burden (in entorhinal and inferior temporal cortices) were assessed using positron emission tomography (PET). Self-awareness of memory was assessed using discrepancy indexes of subjective participant-informant ratings, as well as participant-objective scores of memory performance. Subjective and objective values were derived from the Everyday Cognition memory questionnaire and Logical Memory (delayed recall). Results Lower awareness (both methods) of memory function was associated with higher levels of pathology in the I group as compared to N. There was a significant effect of tauopathy, but not amyloidosis, on individual complaint, such that higher levels of tau associated with lower awareness. Discussion Impaired self-awareness appears progressively in the evolution of the disease related to AD biomarkers. Discordant subjective and objective measures may be important for clinical consideration.https://doi.org/10.1186/s13195-021-00856-xAlzheimer’s diseaseAwarenessCognitionTauAmyloid |
| spellingShingle | Geoffroy Gagliardi Madeline Kuppe Cristina Lois Bernard Hanseeuw Patrizia Vannini for the Alzheimer’s Disease Neuroimaging Initiative Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease Alzheimer’s Research & Therapy Alzheimer’s disease Awareness Cognition Tau Amyloid |
| title | Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease |
| title_full | Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease |
| title_fullStr | Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease |
| title_full_unstemmed | Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease |
| title_short | Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease |
| title_sort | pathological correlates of impaired self awareness of memory function in alzheimer s disease |
| topic | Alzheimer’s disease Awareness Cognition Tau Amyloid |
| url | https://doi.org/10.1186/s13195-021-00856-x |
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