Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging
Mapping tumor hypoxia is a great challenge in Positron Emission Tomography (PET) imaging as the precise functional information of the biological processes is needed for many effective therapeutic strategies. Tumor hypoxia has been widely reported as a poor prognostic indicator and is often associate...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00058/full |
| _version_ | 1818127246259388416 |
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| author | Mathilde eColombié Sébastien eGouard Mathieu eFrindel Aurelien eVidal Michel eChérel Michel eChérel Françoise eKraeber-Bodéré Françoise eKraeber-Bodéré Françoise eKraeber-Bodéré Caroline eRousseau Caroline eRousseau Mickaël eBourgeois Mickaël eBourgeois Mickaël eBourgeois |
| author_facet | Mathilde eColombié Sébastien eGouard Mathieu eFrindel Aurelien eVidal Michel eChérel Michel eChérel Françoise eKraeber-Bodéré Françoise eKraeber-Bodéré Françoise eKraeber-Bodéré Caroline eRousseau Caroline eRousseau Mickaël eBourgeois Mickaël eBourgeois Mickaël eBourgeois |
| author_sort | Mathilde eColombié |
| collection | DOAJ |
| description | Mapping tumor hypoxia is a great challenge in Positron Emission Tomography (PET) imaging as the precise functional information of the biological processes is needed for many effective therapeutic strategies. Tumor hypoxia has been widely reported as a poor prognostic indicator and is often associated with tumor aggressiveness, chemo and radio resistance. An accurate diagnosis of hypoxia is a challenge and is crucial for providing accurate treatment for patients’ survival benefits. This challenge has led to the emergence of new and novel PET tracers for the functional and metabolic characterization of tumor hypoxia non-invasively. Among these tracers, copper semicarbazone compound, [64Cu]- diacetyl-bis(N4 methylthiosemicarbazone) (=64Cu-ATSM) has been developed as a tracer for hypoxia imaging. This review focuses on 64Cu-ATSM PET imaging and the concept is presented in two sections. The first section describes its in vitro development and pre-clinical testing and particularly its affinity in different cell lines. The second section describes the controversial reports on its specificity for hypoxia imaging. The review concludes that 64Cu-ATSM - more than a hypoxic tracer, exhibits tracer accumulation in tumor which is linked to the redox potential and reactive oxygen species (ROS). The authors concluded that 64Cu-ATSNM is a marker of over-reduced cell state and thus an indirect marker for hypoxia imaging. The affinity of 64Cu-ATSM for over reduced cells was observed to be a complex phenomenon. And to provide a definitive and convincing mechanism, more in vivo studies are needed to prove the diagnostic utility of 64Cu-ATSM. |
| first_indexed | 2024-12-11T07:14:18Z |
| format | Article |
| id | doaj.art-ef6b4a3021d1491a9abaf38a5196316a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T07:14:18Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-ef6b4a3021d1491a9abaf38a5196316a2022-12-22T01:16:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2015-08-01210.3389/fmed.2015.00058158385Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imagingMathilde eColombié0Sébastien eGouard1Mathieu eFrindel2Aurelien eVidal3Michel eChérel4Michel eChérel5Françoise eKraeber-Bodéré6Françoise eKraeber-Bodéré7Françoise eKraeber-Bodéré8Caroline eRousseau9Caroline eRousseau10Mickaël eBourgeois11Mickaël eBourgeois12Mickaël eBourgeois13Institut de Cancérologie de l'OuestCRCNA-INSERM U892CRCNA-INSERM U892GIP ARRONAXCRCNA-INSERM U892Institut de Cancérologie de l'OuestCRCNA-INSERM U892Nantes University HospitalInstitut de Cancérologie de l'OuestCRCNA-INSERM U892Institut de Cancérologie de l'OuestCRCNA-INSERM U892Nantes University HospitalGIP ARRONAXMapping tumor hypoxia is a great challenge in Positron Emission Tomography (PET) imaging as the precise functional information of the biological processes is needed for many effective therapeutic strategies. Tumor hypoxia has been widely reported as a poor prognostic indicator and is often associated with tumor aggressiveness, chemo and radio resistance. An accurate diagnosis of hypoxia is a challenge and is crucial for providing accurate treatment for patients’ survival benefits. This challenge has led to the emergence of new and novel PET tracers for the functional and metabolic characterization of tumor hypoxia non-invasively. Among these tracers, copper semicarbazone compound, [64Cu]- diacetyl-bis(N4 methylthiosemicarbazone) (=64Cu-ATSM) has been developed as a tracer for hypoxia imaging. This review focuses on 64Cu-ATSM PET imaging and the concept is presented in two sections. The first section describes its in vitro development and pre-clinical testing and particularly its affinity in different cell lines. The second section describes the controversial reports on its specificity for hypoxia imaging. The review concludes that 64Cu-ATSM - more than a hypoxic tracer, exhibits tracer accumulation in tumor which is linked to the redox potential and reactive oxygen species (ROS). The authors concluded that 64Cu-ATSNM is a marker of over-reduced cell state and thus an indirect marker for hypoxia imaging. The affinity of 64Cu-ATSM for over reduced cells was observed to be a complex phenomenon. And to provide a definitive and convincing mechanism, more in vivo studies are needed to prove the diagnostic utility of 64Cu-ATSM.http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00058/fullCancerhypoxiapositron emission tomographyRadiopharmaceuticalReactive-oxygen-species[64Cu]-ATSM |
| spellingShingle | Mathilde eColombié Sébastien eGouard Mathieu eFrindel Aurelien eVidal Michel eChérel Michel eChérel Françoise eKraeber-Bodéré Françoise eKraeber-Bodéré Françoise eKraeber-Bodéré Caroline eRousseau Caroline eRousseau Mickaël eBourgeois Mickaël eBourgeois Mickaël eBourgeois Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging Frontiers in Medicine Cancer hypoxia positron emission tomography Radiopharmaceutical Reactive-oxygen-species [64Cu]-ATSM |
| title | Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging |
| title_full | Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging |
| title_fullStr | Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging |
| title_full_unstemmed | Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging |
| title_short | Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging |
| title_sort | focus on the controversial aspects of 64cu atsm in tumoral hypoxia mapping by pet imaging |
| topic | Cancer hypoxia positron emission tomography Radiopharmaceutical Reactive-oxygen-species [64Cu]-ATSM |
| url | http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00058/full |
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