Post‐thrombotic syndrome in children: Measurement properties of CAPTSure, a new diagnostic tool
Abstract Background CAPTsure (Clinical Assessment of PTS) is a new tool for diagnosis and severity rating of pediatric postthrombotic syndrome (PTS). Our objective was to test the reliability, measurement error, and minimal detectable change of CAPTSure. Methods Children aged newborn to 18 years who...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rth2.12251 |
| _version_ | 1797710870954901504 |
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| author | Maria Laura Avila Brian M. Feldman Eleanor Pullenayegum Celeste Lumia Madeline I. Montoya Jennifer Vincelli Suzan Williams Leonardo R. Brandão |
| author_facet | Maria Laura Avila Brian M. Feldman Eleanor Pullenayegum Celeste Lumia Madeline I. Montoya Jennifer Vincelli Suzan Williams Leonardo R. Brandão |
| author_sort | Maria Laura Avila |
| collection | DOAJ |
| description | Abstract Background CAPTsure (Clinical Assessment of PTS) is a new tool for diagnosis and severity rating of pediatric postthrombotic syndrome (PTS). Our objective was to test the reliability, measurement error, and minimal detectable change of CAPTSure. Methods Children aged newborn to 18 years who sustained upper extremity or lower extremity deep vein thrombosis (DVT) were enrolled ≥ 6 months after DVT diagnosis. Patients were assessed by 2 raters to determine the reliability of the clinician assessment component (CC) of CAPTSure. Patients/proxies completed CAPTSure at baseline and approximately 2 weeks later to assess test‐retest reliability of the symptoms component (SC). Results Of 148 patients enrolled in the study; 30 had sustained either bilateral or both upper and lower extremity DVT. Hence, 178 extremities were assessed for PTS signs (86 upper extremity, 92 lower extremity). Intraclass correlation coefficient (ICC) for the CC was 0.89 (95% confidence interval [CI], 0.84‐0.93) for upper extremity and 0.88 (95% CI, 0.83‐0.92) for lower extremity. Nonclinicians performed 59% of measurements. Ninety‐eight patients completed the SC at baseline and follow‐up, for a total of 60 upper extremity and 61 lower extremity assessments. ICC for the SC was 0.89 (95% CI, 0.84‐0.93) for upper extremity and 0.92 (0.87‐0.95) for lower extremity. ICC for CAPTSure was 0.92 (95% CI, 0.87‐0.95) for upper extremity and 0.93 (95% CI, 0.88‐0.95) for lower extremity assessment. Measurement error ranged between 1.7 and 4.3 of 100 points. A change of approximately 11 of 100 points in CAPTSure score would be required to be confident that there was a change in PTS severity. Conclusion CAPTSure has excellent reliability and a small measurement error, even when applied by nonhematologists. |
| first_indexed | 2024-03-12T06:57:36Z |
| format | Article |
| id | doaj.art-ef6bb3ca66d249ab9d1f2caf34ee96f4 |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T06:57:36Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-ef6bb3ca66d249ab9d1f2caf34ee96f42023-09-02T23:57:40ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792019-10-013465265710.1002/rth2.12251Post‐thrombotic syndrome in children: Measurement properties of CAPTSure, a new diagnostic toolMaria Laura Avila0Brian M. Feldman1Eleanor Pullenayegum2Celeste Lumia3Madeline I. Montoya4Jennifer Vincelli5Suzan Williams6Leonardo R. Brandão7Department of Pediatrics The Hospital for Sick Children Toronto ON CanadaDepartment of Pediatrics The Hospital for Sick Children Toronto ON CanadaChild Health Evaluative Sciences The Hospital for Sick Children Toronto ON CanadaDepartment of Pediatrics The Hospital for Sick Children Toronto ON CanadaDepartment of Pediatrics The Hospital for Sick Children Toronto ON CanadaDepartment of Pediatrics The Hospital for Sick Children Toronto ON CanadaDepartment of Pediatrics The Hospital for Sick Children Toronto ON CanadaDepartment of Pediatrics The Hospital for Sick Children Toronto ON CanadaAbstract Background CAPTsure (Clinical Assessment of PTS) is a new tool for diagnosis and severity rating of pediatric postthrombotic syndrome (PTS). Our objective was to test the reliability, measurement error, and minimal detectable change of CAPTSure. Methods Children aged newborn to 18 years who sustained upper extremity or lower extremity deep vein thrombosis (DVT) were enrolled ≥ 6 months after DVT diagnosis. Patients were assessed by 2 raters to determine the reliability of the clinician assessment component (CC) of CAPTSure. Patients/proxies completed CAPTSure at baseline and approximately 2 weeks later to assess test‐retest reliability of the symptoms component (SC). Results Of 148 patients enrolled in the study; 30 had sustained either bilateral or both upper and lower extremity DVT. Hence, 178 extremities were assessed for PTS signs (86 upper extremity, 92 lower extremity). Intraclass correlation coefficient (ICC) for the CC was 0.89 (95% confidence interval [CI], 0.84‐0.93) for upper extremity and 0.88 (95% CI, 0.83‐0.92) for lower extremity. Nonclinicians performed 59% of measurements. Ninety‐eight patients completed the SC at baseline and follow‐up, for a total of 60 upper extremity and 61 lower extremity assessments. ICC for the SC was 0.89 (95% CI, 0.84‐0.93) for upper extremity and 0.92 (0.87‐0.95) for lower extremity. ICC for CAPTSure was 0.92 (95% CI, 0.87‐0.95) for upper extremity and 0.93 (95% CI, 0.88‐0.95) for lower extremity assessment. Measurement error ranged between 1.7 and 4.3 of 100 points. A change of approximately 11 of 100 points in CAPTSure score would be required to be confident that there was a change in PTS severity. Conclusion CAPTSure has excellent reliability and a small measurement error, even when applied by nonhematologists.https://doi.org/10.1002/rth2.12251childinfantlower extremitypostthrombotic syndromereproducibility of resultssurveys and questionnaires |
| spellingShingle | Maria Laura Avila Brian M. Feldman Eleanor Pullenayegum Celeste Lumia Madeline I. Montoya Jennifer Vincelli Suzan Williams Leonardo R. Brandão Post‐thrombotic syndrome in children: Measurement properties of CAPTSure, a new diagnostic tool Research and Practice in Thrombosis and Haemostasis child infant lower extremity postthrombotic syndrome reproducibility of results surveys and questionnaires |
| title | Post‐thrombotic syndrome in children: Measurement properties of CAPTSure, a new diagnostic tool |
| title_full | Post‐thrombotic syndrome in children: Measurement properties of CAPTSure, a new diagnostic tool |
| title_fullStr | Post‐thrombotic syndrome in children: Measurement properties of CAPTSure, a new diagnostic tool |
| title_full_unstemmed | Post‐thrombotic syndrome in children: Measurement properties of CAPTSure, a new diagnostic tool |
| title_short | Post‐thrombotic syndrome in children: Measurement properties of CAPTSure, a new diagnostic tool |
| title_sort | post thrombotic syndrome in children measurement properties of captsure a new diagnostic tool |
| topic | child infant lower extremity postthrombotic syndrome reproducibility of results surveys and questionnaires |
| url | https://doi.org/10.1002/rth2.12251 |
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