Primary Immune Thrombocytopenic Purpura (ITP) and ITP Associated with Systemic Lupus Erythematosus: A Review of Clinical Characteristics and Treatment Modalities
Immune thrombocytopenic purpura (ITP) is an immune-mediated disorder characterized by the destruction of platelets and megakaryocytes due to autoantibodies against the platelet surface proteins. ITP without any apparent cause of thrombocytopenia is defined as primary ITP, and ITP in the setting of S...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
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| Series: | International Journal of Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2024/6650921 |
| _version_ | 1797268050196561920 |
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| author | Krishna Prasad Bashyal Sangam Shah Calvin Ghimire Shravya Balmuri Pradip Chaudhary Sandip Karki Anuj Krishna Poudel Ashbina Pokharel Vishal Devarkonda Samina Hayat |
| author_facet | Krishna Prasad Bashyal Sangam Shah Calvin Ghimire Shravya Balmuri Pradip Chaudhary Sandip Karki Anuj Krishna Poudel Ashbina Pokharel Vishal Devarkonda Samina Hayat |
| author_sort | Krishna Prasad Bashyal |
| collection | DOAJ |
| description | Immune thrombocytopenic purpura (ITP) is an immune-mediated disorder characterized by the destruction of platelets and megakaryocytes due to autoantibodies against the platelet surface proteins. ITP without any apparent cause of thrombocytopenia is defined as primary ITP, and ITP in the setting of SLE is secondary ITP, which can be diagnosed after excluding other causes of thrombocytopenia by history, physical examination, and laboratory testing. Patients with ITP associated with SLE have higher median platelet count and less bleeding manifestations compared to the patients with primary ITP. It can be very challenging to diagnose primary ITP in SLE patients as other causes of thrombocytopenia including drug-induced thrombocytopenia, antiphospholipid syndrome, and thrombotic microangiopathic process should be ruled out. Corticosteroids are the main modality of treatment. IVIG can be used in severe cases. Splenectomy was found to be less effective in ITP associated with SLE compared to primary ITP. Control of disease activity with immunosuppressive therapy can be helpful in some cases associated with active disease flares in SLE patients. |
| first_indexed | 2024-04-25T01:26:19Z |
| format | Article |
| id | doaj.art-ef6ce24b92c946bba40796d8e0c3c0cd |
| institution | Directory Open Access Journal |
| issn | 1687-9279 |
| language | English |
| last_indexed | 2024-04-25T01:26:19Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Rheumatology |
| spelling | doaj.art-ef6ce24b92c946bba40796d8e0c3c0cd2024-03-09T00:00:03ZengHindawi LimitedInternational Journal of Rheumatology1687-92792024-01-01202410.1155/2024/6650921Primary Immune Thrombocytopenic Purpura (ITP) and ITP Associated with Systemic Lupus Erythematosus: A Review of Clinical Characteristics and Treatment ModalitiesKrishna Prasad Bashyal0Sangam Shah1Calvin Ghimire2Shravya Balmuri3Pradip Chaudhary4Sandip Karki5Anuj Krishna Poudel6Ashbina Pokharel7Vishal Devarkonda8Samina Hayat9McLaren Health Care CorpTribhuvan UniversityMcLaren Health Care CorpLouisiana State University Health Sciences Centre ShreveportHurley Medical CenterMcLaren Health Care CorpGreater Baltimore Medical CenterWilliam Beaumont HospitalLouisiana State University Health Sciences Centre ShreveportLouisiana State University Health Sciences Centre ShreveportImmune thrombocytopenic purpura (ITP) is an immune-mediated disorder characterized by the destruction of platelets and megakaryocytes due to autoantibodies against the platelet surface proteins. ITP without any apparent cause of thrombocytopenia is defined as primary ITP, and ITP in the setting of SLE is secondary ITP, which can be diagnosed after excluding other causes of thrombocytopenia by history, physical examination, and laboratory testing. Patients with ITP associated with SLE have higher median platelet count and less bleeding manifestations compared to the patients with primary ITP. It can be very challenging to diagnose primary ITP in SLE patients as other causes of thrombocytopenia including drug-induced thrombocytopenia, antiphospholipid syndrome, and thrombotic microangiopathic process should be ruled out. Corticosteroids are the main modality of treatment. IVIG can be used in severe cases. Splenectomy was found to be less effective in ITP associated with SLE compared to primary ITP. Control of disease activity with immunosuppressive therapy can be helpful in some cases associated with active disease flares in SLE patients.http://dx.doi.org/10.1155/2024/6650921 |
| spellingShingle | Krishna Prasad Bashyal Sangam Shah Calvin Ghimire Shravya Balmuri Pradip Chaudhary Sandip Karki Anuj Krishna Poudel Ashbina Pokharel Vishal Devarkonda Samina Hayat Primary Immune Thrombocytopenic Purpura (ITP) and ITP Associated with Systemic Lupus Erythematosus: A Review of Clinical Characteristics and Treatment Modalities International Journal of Rheumatology |
| title | Primary Immune Thrombocytopenic Purpura (ITP) and ITP Associated with Systemic Lupus Erythematosus: A Review of Clinical Characteristics and Treatment Modalities |
| title_full | Primary Immune Thrombocytopenic Purpura (ITP) and ITP Associated with Systemic Lupus Erythematosus: A Review of Clinical Characteristics and Treatment Modalities |
| title_fullStr | Primary Immune Thrombocytopenic Purpura (ITP) and ITP Associated with Systemic Lupus Erythematosus: A Review of Clinical Characteristics and Treatment Modalities |
| title_full_unstemmed | Primary Immune Thrombocytopenic Purpura (ITP) and ITP Associated with Systemic Lupus Erythematosus: A Review of Clinical Characteristics and Treatment Modalities |
| title_short | Primary Immune Thrombocytopenic Purpura (ITP) and ITP Associated with Systemic Lupus Erythematosus: A Review of Clinical Characteristics and Treatment Modalities |
| title_sort | primary immune thrombocytopenic purpura itp and itp associated with systemic lupus erythematosus a review of clinical characteristics and treatment modalities |
| url | http://dx.doi.org/10.1155/2024/6650921 |
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