Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia

Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia

Abstract Childhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome and response to targeted therapy is not known. Here, we present a comprehensive retrospective analysis of paired...

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Bibliographic Details
Main Authors: Amanda C. Lorentzian, Jenna Rever, Enes K. Ergin, Meiyun Guo, Neha M. Akella, Nina Rolf, C. James Lim, Gregor S. D. Reid, Christopher A. Maxwell, Philipp F. Lange
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42701-9

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