Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications
Zinc oxide nanoparticles (ZnO-NPs) have piqued the curiosity of researchers all over the world due to their extensive biological activity. They are less toxic and biodegradable with the capacity to greatly boost pharmacophore bioactivity. ZnO-NPs are the most extensively used metal oxide nanoparticl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/17/3066 |
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| author | Ashok Kumar Mandal Saurav Katuwal Felix Tettey Aakash Gupta Salyan Bhattarai Shankar Jaisi Devi Prasad Bhandari Ajay Kumar Shah Narayan Bhattarai Niranjan Parajuli |
| author_facet | Ashok Kumar Mandal Saurav Katuwal Felix Tettey Aakash Gupta Salyan Bhattarai Shankar Jaisi Devi Prasad Bhandari Ajay Kumar Shah Narayan Bhattarai Niranjan Parajuli |
| author_sort | Ashok Kumar Mandal |
| collection | DOAJ |
| description | Zinc oxide nanoparticles (ZnO-NPs) have piqued the curiosity of researchers all over the world due to their extensive biological activity. They are less toxic and biodegradable with the capacity to greatly boost pharmacophore bioactivity. ZnO-NPs are the most extensively used metal oxide nanoparticles in electronic and optoelectronics because of their distinctive optical and chemical properties which can be readily modified by altering the morphology and the wide bandgap. The biosynthesis of nanoparticles using extracts of therapeutic plants, fungi, bacteria, algae, etc., improves their stability and biocompatibility in many biological settings, and its biofabrication alters its physiochemical behavior, contributing to biological potency. As such, ZnO-NPs can be used as an effective nanocarrier for conventional drugs due to their cost-effectiveness and benefits of being biodegradable and biocompatible. This article covers a comprehensive review of different synthesis approaches of ZnO-NPs including physical, chemical, biochemical, and green synthesis techniques, and also emphasizes their biopotency through antibacterial, antifungal, anticancer, anti-inflammatory, antidiabetic, antioxidant, antiviral, wound healing, and cardioprotective activity. Green synthesis from plants, bacteria, and fungus is given special attention, with a particular emphasis on extraction techniques, precursors used for the synthesis and reaction conditions, characterization techniques, and surface morphology of the particles. |
| first_indexed | 2024-03-10T01:27:18Z |
| format | Article |
| id | doaj.art-ef6d41e43b6048c0a4d2ed159eba4569 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T01:27:18Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ef6d41e43b6048c0a4d2ed159eba45692023-11-23T13:50:18ZengMDPI AGNanomaterials2079-49912022-09-011217306610.3390/nano12173066Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical ApplicationsAshok Kumar Mandal0Saurav Katuwal1Felix Tettey2Aakash Gupta3Salyan Bhattarai4Shankar Jaisi5Devi Prasad Bhandari6Ajay Kumar Shah7Narayan Bhattarai8Niranjan Parajuli9Natural Product Research Laboratory, Thapathali, Kathmandu 44600, NepalCentral Department of Chemistry, Tribhuvan University, Kirtipur 44618, NepalDepartment of Chemical, Biological, and Bioengineering, North Carolina A&T State University, Greensboro, NC 27411, USADepartment of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USAParaza Pharma, Inc., 2525 Avenue Marie-Curie, Montreal, QC H4S 2E1, CanadaCentral Department of Chemistry, Tribhuvan University, Kirtipur 44618, NepalNatural Product Research Laboratory, Thapathali, Kathmandu 44600, NepalFaculty of Health Sciences, School of Health and Allied Sciences, Pokhara University, Lekhnath 33700, NepalDepartment of Chemical, Biological, and Bioengineering, North Carolina A&T State University, Greensboro, NC 27411, USACentral Department of Chemistry, Tribhuvan University, Kirtipur 44618, NepalZinc oxide nanoparticles (ZnO-NPs) have piqued the curiosity of researchers all over the world due to their extensive biological activity. They are less toxic and biodegradable with the capacity to greatly boost pharmacophore bioactivity. ZnO-NPs are the most extensively used metal oxide nanoparticles in electronic and optoelectronics because of their distinctive optical and chemical properties which can be readily modified by altering the morphology and the wide bandgap. The biosynthesis of nanoparticles using extracts of therapeutic plants, fungi, bacteria, algae, etc., improves their stability and biocompatibility in many biological settings, and its biofabrication alters its physiochemical behavior, contributing to biological potency. As such, ZnO-NPs can be used as an effective nanocarrier for conventional drugs due to their cost-effectiveness and benefits of being biodegradable and biocompatible. This article covers a comprehensive review of different synthesis approaches of ZnO-NPs including physical, chemical, biochemical, and green synthesis techniques, and also emphasizes their biopotency through antibacterial, antifungal, anticancer, anti-inflammatory, antidiabetic, antioxidant, antiviral, wound healing, and cardioprotective activity. Green synthesis from plants, bacteria, and fungus is given special attention, with a particular emphasis on extraction techniques, precursors used for the synthesis and reaction conditions, characterization techniques, and surface morphology of the particles.https://www.mdpi.com/2079-4991/12/17/3066zinc oxide nanoparticlesgreen synthesisbiological activities |
| spellingShingle | Ashok Kumar Mandal Saurav Katuwal Felix Tettey Aakash Gupta Salyan Bhattarai Shankar Jaisi Devi Prasad Bhandari Ajay Kumar Shah Narayan Bhattarai Niranjan Parajuli Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications Nanomaterials zinc oxide nanoparticles green synthesis biological activities |
| title | Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications |
| title_full | Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications |
| title_fullStr | Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications |
| title_full_unstemmed | Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications |
| title_short | Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications |
| title_sort | current research on zinc oxide nanoparticles synthesis characterization and biomedical applications |
| topic | zinc oxide nanoparticles green synthesis biological activities |
| url | https://www.mdpi.com/2079-4991/12/17/3066 |
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