Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trials
Abstract Background Liposomal bupivacaine (LB) is a relatively new formulation that slowly releases bupivacaine to extend its efficacy for 72–96 h. It is inconclusive whether LB offers better efficacy than traditional periarticular injection (TPAI) following total knee arthroplasty (TKA). Methods Re...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-03699-4 |
| _version_ | 1797864121827328000 |
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| author | Jian-Jiun Chen Yun-Che Wu Jun-Sing Wang Cheng-Hung Lee |
| author_facet | Jian-Jiun Chen Yun-Che Wu Jun-Sing Wang Cheng-Hung Lee |
| author_sort | Jian-Jiun Chen |
| collection | DOAJ |
| description | Abstract Background Liposomal bupivacaine (LB) is a relatively new formulation that slowly releases bupivacaine to extend its efficacy for 72–96 h. It is inconclusive whether LB offers better efficacy than traditional periarticular injection (TPAI) following total knee arthroplasty (TKA). Methods Relevant randomized controlled trials (RCTs) were searched using electronic databases, including PubMed, Cochrane Library, EMBASE, and Web of Science. Review Manager 5.4.1 was used for calculations. Results Sixteen RCTs were included in this meta-analysis. LB had better effects on morphine consumption equivalents during postoperative 24–48 h than TPAI. No significant difference was observed in pain relief, incidence of nausea and vomiting, or length of hospital stay between the two groups. Conclusion LB administration during TKA is not superior to TPAI. Studies with larger sample size are needed to validate our findings. PROSPERO registration number: CRD42022355094. |
| first_indexed | 2024-04-09T22:46:27Z |
| format | Article |
| id | doaj.art-ef6dda8b06be4cb288bd88d91c6e5b31 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-09T22:46:27Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-ef6dda8b06be4cb288bd88d91c6e5b312023-03-22T11:51:29ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-03-0118111210.1186/s13018-023-03699-4Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trialsJian-Jiun Chen0Yun-Che Wu1Jun-Sing Wang2Cheng-Hung Lee3Department of Orthopedics, Taipei Veterans General HospitalDepartment of Orthopedics, Taichung Veterans General HospitalDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General HospitalDepartment of Orthopedics, Taichung Veterans General HospitalAbstract Background Liposomal bupivacaine (LB) is a relatively new formulation that slowly releases bupivacaine to extend its efficacy for 72–96 h. It is inconclusive whether LB offers better efficacy than traditional periarticular injection (TPAI) following total knee arthroplasty (TKA). Methods Relevant randomized controlled trials (RCTs) were searched using electronic databases, including PubMed, Cochrane Library, EMBASE, and Web of Science. Review Manager 5.4.1 was used for calculations. Results Sixteen RCTs were included in this meta-analysis. LB had better effects on morphine consumption equivalents during postoperative 24–48 h than TPAI. No significant difference was observed in pain relief, incidence of nausea and vomiting, or length of hospital stay between the two groups. Conclusion LB administration during TKA is not superior to TPAI. Studies with larger sample size are needed to validate our findings. PROSPERO registration number: CRD42022355094.https://doi.org/10.1186/s13018-023-03699-4Total knee arthroplastyLiposomal bupivacaineTraditional periarticular injection |
| spellingShingle | Jian-Jiun Chen Yun-Che Wu Jun-Sing Wang Cheng-Hung Lee Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trials Journal of Orthopaedic Surgery and Research Total knee arthroplasty Liposomal bupivacaine Traditional periarticular injection |
| title | Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trials |
| title_full | Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trials |
| title_fullStr | Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trials |
| title_short | Liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty: a meta-analysis of randomized controlled trials |
| title_sort | liposomal bupivacaine administration is not superior to traditional periarticular injection for postoperative pain management following total knee arthroplasty a meta analysis of randomized controlled trials |
| topic | Total knee arthroplasty Liposomal bupivacaine Traditional periarticular injection |
| url | https://doi.org/10.1186/s13018-023-03699-4 |
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