Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer
Obesity is accompanied by a systemic chronic low-grade inflammation as well as dysfunctions of several innate and adaptive immune cells. Recent findings emphasize an impaired functionality and phenotype of natural killer (NK) cells under obese conditions. This review provides a detailed overview on...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00245/full |
| _version_ | 1819261679469330432 |
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| author | Ina Bähr Julia Spielmann Dagmar Quandt Dagmar Quandt Heike Kielstein |
| author_facet | Ina Bähr Julia Spielmann Dagmar Quandt Dagmar Quandt Heike Kielstein |
| author_sort | Ina Bähr |
| collection | DOAJ |
| description | Obesity is accompanied by a systemic chronic low-grade inflammation as well as dysfunctions of several innate and adaptive immune cells. Recent findings emphasize an impaired functionality and phenotype of natural killer (NK) cells under obese conditions. This review provides a detailed overview on research related to overweight and obesity with a particular focus on NK cells. We discuss obesity-associated alterations in subsets, distribution, phenotype, cytotoxicity, cytokine secretion, and signaling cascades of NK cells investigated in vitro as well as in animal and human studies. In addition, we provide recent insights into the effects of physical activity and obesity-associated nutritional factors as well as the reduction of body weight and fat mass on NK cell functions of obese individuals. Finally, we highlight the impact of impaired NK cell physiology on obesity-associated diseases, focusing on the elevated susceptibility for viral infections and increased risk for cancer development and impaired treatment response. |
| first_indexed | 2024-12-23T19:45:38Z |
| format | Article |
| id | doaj.art-ef710ce36c4047d2a15fcefbb03bc1ea |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T19:45:38Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ef710ce36c4047d2a15fcefbb03bc1ea2022-12-21T17:33:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-03-011110.3389/fimmu.2020.00245507098Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of CancerIna Bähr0Julia Spielmann1Dagmar Quandt2Dagmar Quandt3Heike Kielstein4Institute of Anatomy and Cell Biology, Medical Faculty of Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Medical Faculty of Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Medical Faculty of Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyRegenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices, School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, IrelandInstitute of Anatomy and Cell Biology, Medical Faculty of Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyObesity is accompanied by a systemic chronic low-grade inflammation as well as dysfunctions of several innate and adaptive immune cells. Recent findings emphasize an impaired functionality and phenotype of natural killer (NK) cells under obese conditions. This review provides a detailed overview on research related to overweight and obesity with a particular focus on NK cells. We discuss obesity-associated alterations in subsets, distribution, phenotype, cytotoxicity, cytokine secretion, and signaling cascades of NK cells investigated in vitro as well as in animal and human studies. In addition, we provide recent insights into the effects of physical activity and obesity-associated nutritional factors as well as the reduction of body weight and fat mass on NK cell functions of obese individuals. Finally, we highlight the impact of impaired NK cell physiology on obesity-associated diseases, focusing on the elevated susceptibility for viral infections and increased risk for cancer development and impaired treatment response.https://www.frontiersin.org/article/10.3389/fimmu.2020.00245/fullNK cellsobesityadipokinesinflammationcancerprevention |
| spellingShingle | Ina Bähr Julia Spielmann Dagmar Quandt Dagmar Quandt Heike Kielstein Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer Frontiers in Immunology NK cells obesity adipokines inflammation cancer prevention |
| title | Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer |
| title_full | Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer |
| title_fullStr | Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer |
| title_full_unstemmed | Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer |
| title_short | Obesity-Associated Alterations of Natural Killer Cells and Immunosurveillance of Cancer |
| title_sort | obesity associated alterations of natural killer cells and immunosurveillance of cancer |
| topic | NK cells obesity adipokines inflammation cancer prevention |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00245/full |
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