Hepatic passaging of NRAS-mutant melanoma influences adhesive properties and metastatic pattern

Hepatic passaging of NRAS-mutant melanoma influences adhesive properties and metastatic pattern

Abstract Background Liver metastasis is a poor prognostic factor for treatment of advanced cutaneous melanoma with either immunotherapy or targeted therapies. In this study we focused on NRAS mutated melanoma, a cohort with high unmet clinical need. Methods WT31 melanoma was repeatedly passaged over...

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Bibliographic Details
Main Authors: Bianca Dietsch, Céline Weller, Carsten Sticht, Carolina de la Torre, Martin Kramer, Sergij Goerdt, Cyrill Géraud, Sebastian A. Wohlfeil
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Cancer
Subjects:
Cutaneous melanoma
Melanoma metastasis
Liver metastasis
Tumor heterogeneity
Online Access:https://doi.org/10.1186/s12885-023-10912-4

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