Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CF<sub>3</sub>CN

Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CF<sub>3</sub>CN

We herein describe a general approach to 5-trifluoromethyl 1,2,4-triazoles via the [3 + 2]-cycloaddition of nitrile imines generated in situ from hydrazonyl chloride with CF<sub>3</sub>CN, utilizing 2,2,2-trifluoroacetaldehyde <i>O</i>-(aryl)oxime as the precursor of trifluor...

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Bibliographic Details
Main Authors: Bo Lin, Zipeng Zhang, Yunfei Yao, Yi You, Zhiqiang Weng
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
trifluoromethyl
triazole
cycloaddition
nitrile imines
trifluoroacetonitrile
Online Access:https://www.mdpi.com/1420-3049/27/19/6568

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