Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in Rats
To evaluate the effects of iloprost administration before unilateral nephrectomy on postoperative interleukin-6 (IL-6), nitric oxide (NO), and oxidant/antioxidant status. METHODS: Malondialdehyde, glutathione, catalase and Cu-Zn superoxide dismutase were measured in the blood and remnant kidney of A...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2008-04-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958408600615 |
| _version_ | 1818022509049544704 |
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| author | Erman Aytac Pinar Seymen Goksel Dikmen Hafize Uzun Hakki Oktay Seymen |
| author_facet | Erman Aytac Pinar Seymen Goksel Dikmen Hafize Uzun Hakki Oktay Seymen |
| author_sort | Erman Aytac |
| collection | DOAJ |
| description | To evaluate the effects of iloprost administration before unilateral nephrectomy on postoperative interleukin-6 (IL-6), nitric oxide (NO), and oxidant/antioxidant status.
METHODS: Malondialdehyde, glutathione, catalase and Cu-Zn superoxide dismutase were measured in the blood and remnant kidney of Adult male Wistar albino rats to asses oxidant and antioxidant status. The rats were divided into three experimental groups: sham group (S) (n = 12); unilateral nephrectomized group (N) (n = 12); an hour before unilateral nephrectomy iloprost (1 ng/mL/kg, intraperitoneal) administered group (IN) (n = 12).
RESULTS: Iloprost administration before unilateral nephrectomy lowered oxidant parameters and IL-6 levels significantly. NO levels were increased in both N and IN groups.
CONCLUSION: Iloprost pretreatment before unilateral nephrectomy can reduce oxidative stress and IL-6, which increases due to anaesthesia and surgery and causes organ damage during surgery and in the short-term postoperative period. |
| first_indexed | 2024-12-10T03:29:33Z |
| format | Article |
| id | doaj.art-ef7529f8038b4b508024ff815e3005fb |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-10T03:29:33Z |
| publishDate | 2008-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-ef7529f8038b4b508024ff815e3005fb2022-12-22T02:03:51ZengElsevierAsian Journal of Surgery1015-95842008-04-01312697410.1016/S1015-9584(08)60061-5Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in RatsErman Aytac0Pinar Seymen1Goksel Dikmen2Hafize Uzun3Hakki Oktay Seymen4Departments of General Surgery, Haydarpasa Numune Research and Training Hospital, Istanbul, TurkeyDivision of Nephrology, Department of Internal Medicine, Haydarpasa Numune Research and Training Hospital, Istanbul, TurkeyDepartment of Orthopedics, Istanbul Medical Faculty, Istanbul University, Haydarpasa Numune Research and Training Hospital, Istanbul, TurkeyDepartments of Biochemistry, Haydarpasa Numune Research and Training Hospital, Istanbul, TurkeyDepartments of Physiology, Cerrahpasa Medical Faculty, Haydarpasa Numune Research and Training Hospital, Istanbul, TurkeyTo evaluate the effects of iloprost administration before unilateral nephrectomy on postoperative interleukin-6 (IL-6), nitric oxide (NO), and oxidant/antioxidant status. METHODS: Malondialdehyde, glutathione, catalase and Cu-Zn superoxide dismutase were measured in the blood and remnant kidney of Adult male Wistar albino rats to asses oxidant and antioxidant status. The rats were divided into three experimental groups: sham group (S) (n = 12); unilateral nephrectomized group (N) (n = 12); an hour before unilateral nephrectomy iloprost (1 ng/mL/kg, intraperitoneal) administered group (IN) (n = 12). RESULTS: Iloprost administration before unilateral nephrectomy lowered oxidant parameters and IL-6 levels significantly. NO levels were increased in both N and IN groups. CONCLUSION: Iloprost pretreatment before unilateral nephrectomy can reduce oxidative stress and IL-6, which increases due to anaesthesia and surgery and causes organ damage during surgery and in the short-term postoperative period.http://www.sciencedirect.com/science/article/pii/S1015958408600615iloprostinterleukin-6nitric oxideoxidative stressunilateral nephrectomy |
| spellingShingle | Erman Aytac Pinar Seymen Goksel Dikmen Hafize Uzun Hakki Oktay Seymen Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in Rats Asian Journal of Surgery iloprost interleukin-6 nitric oxide oxidative stress unilateral nephrectomy |
| title | Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in Rats |
| title_full | Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in Rats |
| title_fullStr | Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in Rats |
| title_full_unstemmed | Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in Rats |
| title_short | Iloprost Pretreatment Before Unilateral Nephrectomy: An Experimental Study in Rats |
| title_sort | iloprost pretreatment before unilateral nephrectomy an experimental study in rats |
| topic | iloprost interleukin-6 nitric oxide oxidative stress unilateral nephrectomy |
| url | http://www.sciencedirect.com/science/article/pii/S1015958408600615 |
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