Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules
Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the anal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-04-01
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| Series: | Nanomaterials |
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| Online Access: | http://www.mdpi.com/2079-4991/7/4/87 |
| _version_ | 1819014631723630592 |
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| author | Minghua Lu Xueqing Yang Yixin Yang Peige Qin Xiuru Wu Zongwei Cai |
| author_facet | Minghua Lu Xueqing Yang Yixin Yang Peige Qin Xiuru Wu Zongwei Cai |
| author_sort | Minghua Lu |
| collection | DOAJ |
| description | Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds. |
| first_indexed | 2024-12-21T02:18:55Z |
| format | Article |
| id | doaj.art-ef75c5a579a644c38a398bce5f5186ba |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-21T02:18:55Z |
| publishDate | 2017-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ef75c5a579a644c38a398bce5f5186ba2022-12-21T19:19:13ZengMDPI AGNanomaterials2079-49912017-04-01748710.3390/nano7040087nano7040087Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small MoleculesMinghua Lu0Xueqing Yang1Yixin Yang2Peige Qin3Xiuru Wu4Zongwei Cai5Institute of Environmental and Analysis Science, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, Henan, ChinaState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, ChinaInstitute of Environmental and Analysis Science, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, Henan, ChinaInstitute of Environmental and Analysis Science, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, Henan, ChinaInstitute of Environmental and Analysis Science, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, Henan, ChinaState Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, ChinaMatrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds.http://www.mdpi.com/2079-4991/7/4/87nanomateriallaser desorption/ionizationtime-of-flight mass spectrometrysmall biological moleculesenvironmental pollutants |
| spellingShingle | Minghua Lu Xueqing Yang Yixin Yang Peige Qin Xiuru Wu Zongwei Cai Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules Nanomaterials nanomaterial laser desorption/ionization time-of-flight mass spectrometry small biological molecules environmental pollutants |
| title | Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules |
| title_full | Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules |
| title_fullStr | Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules |
| title_full_unstemmed | Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules |
| title_short | Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules |
| title_sort | nanomaterials as assisted matrix of laser desorption ionization time of flight mass spectrometry for the analysis of small molecules |
| topic | nanomaterial laser desorption/ionization time-of-flight mass spectrometry small biological molecules environmental pollutants |
| url | http://www.mdpi.com/2079-4991/7/4/87 |
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