Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a murine macrophage cell line

Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a murine macrophage cell line

Abstract:Mycobacterium bovis (M. bovis) is highly adapted to macrophages and has developed multiple mechanisms to resist intracellular assaults. However, the host cells in turn deploy a multipronged defense mechanism to control bacterial infection. Endoplasmic reticulum (ER) stress-mediated apoptosi...

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Bibliographic Details
Main Authors: Yongyong Cui, Deming Zhao, Srinand Sreevastan, Chunfa Liu, Wei Yang, Zhiqi Song, Lifeng Yang, Paul Barrow, Xiangmei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Apoptosis
Mycobacterium
IRF3
M. bovis
ER stress response
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00182/full

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