Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana

Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana

ABSTRACT Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified. Using a combination of unbiased orthogonal organic phase sepa...

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Bibliographic Details
Main Authors: Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros I. Roumeliotis, Jyoti Choudhary, Paul W. Denny
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
RNA-binding proteins
Leishmania
OOPS
TMT labeling
LC-MS/MS
RNA-seq
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02422-21

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