Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis
ABSTRACT Objective: To assess the effects of atorvastatin calcium in the treatment of dexamethasone-induced osteoporosis. Methods: Osteoporosis induction consisted of the administration of an intramuscular dose of 7.5 mg/kg of body weight of dexamethasone, once a week for four weeks, except for th...
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Sociedade Brasileira de Ortopedia e Traumatologia
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| author | Davilson Bragine Ferreira Junior Virgínia Ramos Pizziolo Tânia Toledo de Oliveira Sérgio Luis Pinto da Matta Mayra Soares Píccolo José Humberto de Queiroz |
| author_facet | Davilson Bragine Ferreira Junior Virgínia Ramos Pizziolo Tânia Toledo de Oliveira Sérgio Luis Pinto da Matta Mayra Soares Píccolo José Humberto de Queiroz |
| author_sort | Davilson Bragine Ferreira Junior |
| collection | DOAJ |
| description | ABSTRACT Objective: To assess the effects of atorvastatin calcium in the treatment of dexamethasone-induced osteoporosis. Methods: Osteoporosis induction consisted of the administration of an intramuscular dose of 7.5 mg/kg of body weight of dexamethasone, once a week for four weeks, except for the control animals (G1). The animals were divided into the following groups: G1 (control group without osteoporosis), G2 (control group with untreated osteoporosis), G3 (control group with osteoporosis treated with sodium alendronate 0.2 mg/kg) and G4 (group with osteoporosis treated with atorvastatin calcium 1.2 mg/kg). Serum alkaline phosphatase, bone alkaline phosphatase, and biometric and bone histomorphometric assessments were performed after 30 and 60 days of treatment onset. Results: In relation to the biometric and histomorphometric analyses, at 60 days of treatment, G4 presented bone density (Seedor index), bone trabecular density, and cortical thickness of 0.222 ± 0.004 g/cm, 59.167 ± 2.401%, and 387,501 ± 8573 µm, respectively, with a positive and statistically significant difference (p < 0.05), in relation to G2. At 30 and 60 days of treatment, G4 presented statistically significant serum levels of alkaline phosphatase alkaline phosphatase (p < 0.05) that were higher than all groups (7.451 ± 0.173 µg/L and 7.473 ± 0.529 µg/L, respectively). Conclusion: Treatment with atorvastatin calcium demonstrated the ability of this drug to increase osteoblastic activity and bone tissue repair activity, acting differently from alendronate sodium, which demonstrated predominantly antirebsorptive activity. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1982-4378 |
| language | English |
| last_indexed | 2024-03-08T07:21:49Z |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Revista Brasileira de Ortopedia |
| spelling | doaj.art-ef78d8c6a0ff49379109adf8c55fc5202024-02-02T23:29:25ZengSociedade Brasileira de Ortopedia e TraumatologiaRevista Brasileira de Ortopedia1982-437853560761310.1016/j.rboe.2018.07.007S0102-36162018000500607Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosisDavilson Bragine Ferreira JuniorVirgínia Ramos PizzioloTânia Toledo de OliveiraSérgio Luis Pinto da MattaMayra Soares PíccoloJosé Humberto de QueirozABSTRACT Objective: To assess the effects of atorvastatin calcium in the treatment of dexamethasone-induced osteoporosis. Methods: Osteoporosis induction consisted of the administration of an intramuscular dose of 7.5 mg/kg of body weight of dexamethasone, once a week for four weeks, except for the control animals (G1). The animals were divided into the following groups: G1 (control group without osteoporosis), G2 (control group with untreated osteoporosis), G3 (control group with osteoporosis treated with sodium alendronate 0.2 mg/kg) and G4 (group with osteoporosis treated with atorvastatin calcium 1.2 mg/kg). Serum alkaline phosphatase, bone alkaline phosphatase, and biometric and bone histomorphometric assessments were performed after 30 and 60 days of treatment onset. Results: In relation to the biometric and histomorphometric analyses, at 60 days of treatment, G4 presented bone density (Seedor index), bone trabecular density, and cortical thickness of 0.222 ± 0.004 g/cm, 59.167 ± 2.401%, and 387,501 ± 8573 µm, respectively, with a positive and statistically significant difference (p < 0.05), in relation to G2. At 30 and 60 days of treatment, G4 presented statistically significant serum levels of alkaline phosphatase alkaline phosphatase (p < 0.05) that were higher than all groups (7.451 ± 0.173 µg/L and 7.473 ± 0.529 µg/L, respectively). Conclusion: Treatment with atorvastatin calcium demonstrated the ability of this drug to increase osteoblastic activity and bone tissue repair activity, acting differently from alendronate sodium, which demonstrated predominantly antirebsorptive activity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000500607&lng=en&tlng=enGlucocorticoidDiphosphonatesAlendronateAlkaline phosphataseBone histomorphometry |
| spellingShingle | Davilson Bragine Ferreira Junior Virgínia Ramos Pizziolo Tânia Toledo de Oliveira Sérgio Luis Pinto da Matta Mayra Soares Píccolo José Humberto de Queiroz Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis Revista Brasileira de Ortopedia Glucocorticoid Diphosphonates Alendronate Alkaline phosphatase Bone histomorphometry |
| title | Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis |
| title_full | Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis |
| title_fullStr | Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis |
| title_full_unstemmed | Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis |
| title_short | Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis |
| title_sort | biometric histomorphometric and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone induced osteoporosis |
| topic | Glucocorticoid Diphosphonates Alendronate Alkaline phosphatase Bone histomorphometry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162018000500607&lng=en&tlng=en |
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