The Fyn-STAT5 pathway: A New Frontier in IgE and IgG-Mediated Mast Cell Signaling
Mast cells are central players in immune surveillance and activation, positioned at the host-environment interface. Understanding the signaling events controlling mast cell function, especially those that maintain host homeostasis, is an important and still less understood area of mast cell-mediated...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00117/full |
| _version_ | 1818956552775663616 |
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| author | Nicholas A. Pullen Yves T. Falanga Johanna K. Morales John J. Ryan |
| author_facet | Nicholas A. Pullen Yves T. Falanga Johanna K. Morales John J. Ryan |
| author_sort | Nicholas A. Pullen |
| collection | DOAJ |
| description | Mast cells are central players in immune surveillance and activation, positioned at the host-environment interface. Understanding the signaling events controlling mast cell function, especially those that maintain host homeostasis, is an important and still less understood area of mast cell-mediated disease. With respect to allergic disease, it is well established that IgE and its high affinity receptor FcεRI are major mediators of mast cell activation. However, IgG-mediated signals can also modulate mast cell activities. Signals elicited by IgG binding to its cognate receptors (FcγR) are the basis for autoimmune disorders such as lupus and rheumatoid arthritis. Using knowledge of IgE-mediated mast cell signaling, recent work has begun to illuminate potential overlap between FcεRI and FcγR signal transduction. Herein we review the importance of Src family kinases in FcεRI and FcγR signaling, the role of the transcription factor STAT5, and impingement of the regulatory cytokines IL-4, IL-10, and TGFβ1 upon this network. |
| first_indexed | 2024-12-20T10:55:47Z |
| format | Article |
| id | doaj.art-ef7a7c28146b459dbb6a8ff60453df05 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T10:55:47Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ef7a7c28146b459dbb6a8ff60453df052022-12-21T19:43:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-05-01310.3389/fimmu.2012.0011721799The Fyn-STAT5 pathway: A New Frontier in IgE and IgG-Mediated Mast Cell SignalingNicholas A. Pullen0Yves T. Falanga1Johanna K. Morales2John J. Ryan3Virginia Commonwealth UniversityVirginia Commonwealth UniversityVirginia Commonwealth UniversityVirginia Commonwealth UniversityMast cells are central players in immune surveillance and activation, positioned at the host-environment interface. Understanding the signaling events controlling mast cell function, especially those that maintain host homeostasis, is an important and still less understood area of mast cell-mediated disease. With respect to allergic disease, it is well established that IgE and its high affinity receptor FcεRI are major mediators of mast cell activation. However, IgG-mediated signals can also modulate mast cell activities. Signals elicited by IgG binding to its cognate receptors (FcγR) are the basis for autoimmune disorders such as lupus and rheumatoid arthritis. Using knowledge of IgE-mediated mast cell signaling, recent work has begun to illuminate potential overlap between FcεRI and FcγR signal transduction. Herein we review the importance of Src family kinases in FcεRI and FcγR signaling, the role of the transcription factor STAT5, and impingement of the regulatory cytokines IL-4, IL-10, and TGFβ1 upon this network.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00117/fullmast cellStat5FynIgEIgGIL-4 |
| spellingShingle | Nicholas A. Pullen Yves T. Falanga Johanna K. Morales John J. Ryan The Fyn-STAT5 pathway: A New Frontier in IgE and IgG-Mediated Mast Cell Signaling Frontiers in Immunology mast cell Stat5 Fyn IgE IgG IL-4 |
| title | The Fyn-STAT5 pathway: A New Frontier in IgE and IgG-Mediated Mast Cell Signaling |
| title_full | The Fyn-STAT5 pathway: A New Frontier in IgE and IgG-Mediated Mast Cell Signaling |
| title_fullStr | The Fyn-STAT5 pathway: A New Frontier in IgE and IgG-Mediated Mast Cell Signaling |
| title_full_unstemmed | The Fyn-STAT5 pathway: A New Frontier in IgE and IgG-Mediated Mast Cell Signaling |
| title_short | The Fyn-STAT5 pathway: A New Frontier in IgE and IgG-Mediated Mast Cell Signaling |
| title_sort | fyn stat5 pathway a new frontier in ige and igg mediated mast cell signaling |
| topic | mast cell Stat5 Fyn IgE IgG IL-4 |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00117/full |
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