Immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor
Background/aim: Angiogenesis is the formation of new vessels from preexisting ones. The aim of our study was to determine the relevance of tumor-induced angiogenesis, its correlation with some of the commonly used clinical, pathological factors and the recent biological indicators, and metastatic po...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defence, Serbia
2006-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500607635I.pdf |
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| author | Ivković-Kapicl Tatjana Knežević-Ušaj Slavica Panjković Milana Mastilović Katarina |
| author_facet | Ivković-Kapicl Tatjana Knežević-Ušaj Slavica Panjković Milana Mastilović Katarina |
| author_sort | Ivković-Kapicl Tatjana |
| collection | DOAJ |
| description | Background/aim: Angiogenesis is the formation of new vessels from preexisting ones. The aim of our study was to determine the relevance of tumor-induced angiogenesis, its correlation with some of the commonly used clinical, pathological factors and the recent biological indicators, and metastatic potential of the tumor in a series of 120 patients with invasive ductal carcinoma of the breast. Methods. The identification of microvessels was performed immunohistochemically with factor VIII-related antigen. The microvessel count (MVC) was assessed at the invasive front of each carcinoma. The cases were divided into high-and low-microvessel density groups according to an average number of microvessels found in the multiple fields of the most vessel-dense part of each tumor. The nuclear immunohistochemical staining for hormone receptors, and the p53, and the membranous staining for cerbB-2 were evaluated. Results. There were significant correlations between a high MVC and a large tumor size, high histological grade, and c-erbB-2 protein over expression. There was no association between tumor angiogenesis, as assessed by the MVC, and the hormone receptors status, and the p53 protein expression. In the cases with a high MVC, there was a significant number of tumors with lymph node metastases. Conclusion. Our findings showed that a high MVC might point out an aggressive tumor phenotype. This might help to stratify patients for an appropriate therapy on an individual basis and, thus, offer the possibility of a more effectively tailored treatment program. |
| first_indexed | 2024-12-13T02:57:16Z |
| format | Article |
| id | doaj.art-ef7ba5281a26492da78f71c6ec17047f |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2025-03-14T13:03:42Z |
| publishDate | 2006-01-01 |
| publisher | Military Health Department, Ministry of Defence, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-ef7ba5281a26492da78f71c6ec17047f2025-03-02T02:29:27ZengMilitary Health Department, Ministry of Defence, SerbiaVojnosanitetski Pregled0042-84502006-01-0163763564210.2298/VSP0607635IImmunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factorIvković-Kapicl TatjanaKnežević-Ušaj SlavicaPanjković MilanaMastilović KatarinaBackground/aim: Angiogenesis is the formation of new vessels from preexisting ones. The aim of our study was to determine the relevance of tumor-induced angiogenesis, its correlation with some of the commonly used clinical, pathological factors and the recent biological indicators, and metastatic potential of the tumor in a series of 120 patients with invasive ductal carcinoma of the breast. Methods. The identification of microvessels was performed immunohistochemically with factor VIII-related antigen. The microvessel count (MVC) was assessed at the invasive front of each carcinoma. The cases were divided into high-and low-microvessel density groups according to an average number of microvessels found in the multiple fields of the most vessel-dense part of each tumor. The nuclear immunohistochemical staining for hormone receptors, and the p53, and the membranous staining for cerbB-2 were evaluated. Results. There were significant correlations between a high MVC and a large tumor size, high histological grade, and c-erbB-2 protein over expression. There was no association between tumor angiogenesis, as assessed by the MVC, and the hormone receptors status, and the p53 protein expression. In the cases with a high MVC, there was a significant number of tumors with lymph node metastases. Conclusion. Our findings showed that a high MVC might point out an aggressive tumor phenotype. This might help to stratify patients for an appropriate therapy on an individual basis and, thus, offer the possibility of a more effectively tailored treatment program.http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500607635I.pdfbreast neoplasmscarcinomaductalbreastneovascularizationpathologicimmunohistochemistryprognosis |
| spellingShingle | Ivković-Kapicl Tatjana Knežević-Ušaj Slavica Panjković Milana Mastilović Katarina Immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor Vojnosanitetski Pregled breast neoplasms carcinoma ductal breast neovascularization pathologic immunohistochemistry prognosis |
| title | Immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor |
| title_full | Immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor |
| title_fullStr | Immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor |
| title_full_unstemmed | Immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor |
| title_short | Immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor |
| title_sort | immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor |
| topic | breast neoplasms carcinoma ductal breast neovascularization pathologic immunohistochemistry prognosis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500607635I.pdf |
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