Measurement of Magnesium, Zinc, and Copper in Human Serum by Using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry (ID ICP-MS)
In order to evaluate the reliability of the ID ICP-MS method for the measurement of magnesium, zinc, and copper in human serum, we investigated the traceability, precision, trueness, and uncertainty of the method. This method traces the contents of magnesium, zinc, and copper in human serum to the s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2023/6612672 |
| _version_ | 1797659080004730880 |
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| author | Jian Yang Lixia Chi Shengmin Li |
| author_facet | Jian Yang Lixia Chi Shengmin Li |
| author_sort | Jian Yang |
| collection | DOAJ |
| description | In order to evaluate the reliability of the ID ICP-MS method for the measurement of magnesium, zinc, and copper in human serum, we investigated the traceability, precision, trueness, and uncertainty of the method. This method traces the contents of magnesium, zinc, and copper in human serum to the standard materials NIST SRM3131a, SRM3168a, and SRM3114 respectively, thus completing the traceability to SI unit. The repeatability of this method for measuring magnesium, zinc, and copper in the human serum reference material GBW09152 was found to be 0.2%, 0.7%, and 0.6% (n = 9), respectively. The measurement, when employed to measure the magnesium, zinc, and copper in standard materials, had caused a maximum deviation of less than 0.88%, 1.35%, and 1.15%, respectively. The measurement results are within the stated uncertainty range of standard materials. The expanded uncertainties were 0.2 mg·kg−1, 0.04 mg·kg−1, and 0.08 mg·kg−1 (K = 2) for magnesium, zinc, and copper, respectively. Therefore, this method has high trueness, good reproducibility, and simple operation and is suitable for tracing the values of magnesium, zinc, and copper in human serum. |
| first_indexed | 2024-03-11T18:08:46Z |
| format | Article |
| id | doaj.art-ef7d9ce132d4465e91cb606d25b15867 |
| institution | Directory Open Access Journal |
| issn | 1687-8779 |
| language | English |
| last_indexed | 2024-03-11T18:08:46Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj.art-ef7d9ce132d4465e91cb606d25b158672023-10-17T00:00:01ZengHindawi LimitedInternational Journal of Analytical Chemistry1687-87792023-01-01202310.1155/2023/6612672Measurement of Magnesium, Zinc, and Copper in Human Serum by Using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry (ID ICP-MS)Jian Yang0Lixia Chi1Shengmin Li2Institute of Disaster PreventionInstitute of Disaster PreventionBeijing Institute of Medical Device TestingIn order to evaluate the reliability of the ID ICP-MS method for the measurement of magnesium, zinc, and copper in human serum, we investigated the traceability, precision, trueness, and uncertainty of the method. This method traces the contents of magnesium, zinc, and copper in human serum to the standard materials NIST SRM3131a, SRM3168a, and SRM3114 respectively, thus completing the traceability to SI unit. The repeatability of this method for measuring magnesium, zinc, and copper in the human serum reference material GBW09152 was found to be 0.2%, 0.7%, and 0.6% (n = 9), respectively. The measurement, when employed to measure the magnesium, zinc, and copper in standard materials, had caused a maximum deviation of less than 0.88%, 1.35%, and 1.15%, respectively. The measurement results are within the stated uncertainty range of standard materials. The expanded uncertainties were 0.2 mg·kg−1, 0.04 mg·kg−1, and 0.08 mg·kg−1 (K = 2) for magnesium, zinc, and copper, respectively. Therefore, this method has high trueness, good reproducibility, and simple operation and is suitable for tracing the values of magnesium, zinc, and copper in human serum.http://dx.doi.org/10.1155/2023/6612672 |
| spellingShingle | Jian Yang Lixia Chi Shengmin Li Measurement of Magnesium, Zinc, and Copper in Human Serum by Using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry (ID ICP-MS) International Journal of Analytical Chemistry |
| title | Measurement of Magnesium, Zinc, and Copper in Human Serum by Using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry (ID ICP-MS) |
| title_full | Measurement of Magnesium, Zinc, and Copper in Human Serum by Using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry (ID ICP-MS) |
| title_fullStr | Measurement of Magnesium, Zinc, and Copper in Human Serum by Using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry (ID ICP-MS) |
| title_full_unstemmed | Measurement of Magnesium, Zinc, and Copper in Human Serum by Using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry (ID ICP-MS) |
| title_short | Measurement of Magnesium, Zinc, and Copper in Human Serum by Using Isotope Dilution Inductively Coupled Plasma Mass Spectrometry (ID ICP-MS) |
| title_sort | measurement of magnesium zinc and copper in human serum by using isotope dilution inductively coupled plasma mass spectrometry id icp ms |
| url | http://dx.doi.org/10.1155/2023/6612672 |
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