Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individuals
Objectives We explored whether adapting neuropsychological tests for online administration during the COVID-19 pandemic was feasible for dementia research.Design We used a longitudinal design for healthy controls, who completed face-to-face assessments 3–4 years before remote assessments. For patien...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/11/e064576.full |
| _version_ | 1828098253488390144 |
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| author | Jason D Warren Jonathan D Rohrer Caroline Greaves Lucianne Dobson Rebecca L Bond Chris JD Hardy Sebastian J Crutch Jessica Jiang Elia Benhamou Mai-Carmen Requena-Komuro Suzie Barker Lucy Russell Emilie V Brotherhood |
| author_facet | Jason D Warren Jonathan D Rohrer Caroline Greaves Lucianne Dobson Rebecca L Bond Chris JD Hardy Sebastian J Crutch Jessica Jiang Elia Benhamou Mai-Carmen Requena-Komuro Suzie Barker Lucy Russell Emilie V Brotherhood |
| author_sort | Jason D Warren |
| collection | DOAJ |
| description | Objectives We explored whether adapting neuropsychological tests for online administration during the COVID-19 pandemic was feasible for dementia research.Design We used a longitudinal design for healthy controls, who completed face-to-face assessments 3–4 years before remote assessments. For patients, we used a cross-sectional design, contrasting a prospective remote cohort with a retrospective face-to-face cohort matched for age/education/severity.Setting Remote assessments were conducted using video-conferencing/online testing platforms, with participants using a personal computer/tablet at home. Face-to-face assessments were conducted in testing rooms at our research centre.Participants The remote cohort comprised 25 patients (n=8 Alzheimer’s disease (AD); n=3 behavioural variant frontotemporal dementia (bvFTD); n=4 semantic dementia (SD); n=5 progressive non-fluent aphasia (PNFA); n=5 logopenic aphasia (LPA)). The face-to-face patient cohort comprised 64 patients (n=25 AD; n=12 bvFTD; n=9 SD; n=12 PNFA; n=6 LPA). Ten controls who previously participated in face-to-face research also took part remotely.Outcome measures The outcome measures comprised the strength of evidence under a Bayesian framework for differences in performances between testing environments on general neuropsychological and neurolinguistic measures.Results There was substantial evidence suggesting no difference across environments in both the healthy control and combined patient cohorts (including measures of working memory, single-word comprehension, arithmetic and naming; Bayes Factors (BF)01 >3), in the healthy control group alone (including measures of letter/category fluency, semantic knowledge and bisyllabic word repetition; all BF01 >3), and in the combined patient cohort alone (including measures of working memory, episodic memory, short-term verbal memory, visual perception, non-word reading, sentence comprehension and bisyllabic/trisyllabic word repetition; all BF01 >3). In the control cohort alone, there was substantial evidence in support of a difference across environments for tests of visual perception (BF01=0.0404) and monosyllabic word repetition (BF01=0.0487).Conclusions Our findings suggest that remote delivery of neuropsychological tests for dementia research is feasible. |
| first_indexed | 2024-04-11T07:59:43Z |
| format | Article |
| id | doaj.art-ef7dd2b33cb64c79a824d652821af8ce |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-11T07:59:43Z |
| publishDate | 2022-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-ef7dd2b33cb64c79a824d652821af8ce2022-12-22T04:35:48ZengBMJ Publishing GroupBMJ Open2044-60552022-11-01121110.1136/bmjopen-2022-064576Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individualsJason D Warren0Jonathan D Rohrer1Caroline Greaves2Lucianne Dobson3Rebecca L Bond4Chris JD Hardy5Sebastian J Crutch6Jessica Jiang7Elia Benhamou8Mai-Carmen Requena-Komuro9Suzie Barker10Lucy Russell11Emilie V Brotherhood121 Dementia Research Centre, UCL, London, UKhonorary consultant neurologistDementia Research Centre, University College London, London, UK1Dementia Research Centre, UCL Queen Square Institute of Neurology1Dementia Research Centre, UCL Queen Square Institute of Neurology, University College LondonQueen Square Institute of Neurology, London1 Dementia Research Centre, UCL, London, UK1University College London1University College London1University College LondonDementia Research Centre, UCL Queen Square Institute of Neurology, London, UKDementia Research Centre, University College London, London, UKDementia Research Centre, University College London, London, UKObjectives We explored whether adapting neuropsychological tests for online administration during the COVID-19 pandemic was feasible for dementia research.Design We used a longitudinal design for healthy controls, who completed face-to-face assessments 3–4 years before remote assessments. For patients, we used a cross-sectional design, contrasting a prospective remote cohort with a retrospective face-to-face cohort matched for age/education/severity.Setting Remote assessments were conducted using video-conferencing/online testing platforms, with participants using a personal computer/tablet at home. Face-to-face assessments were conducted in testing rooms at our research centre.Participants The remote cohort comprised 25 patients (n=8 Alzheimer’s disease (AD); n=3 behavioural variant frontotemporal dementia (bvFTD); n=4 semantic dementia (SD); n=5 progressive non-fluent aphasia (PNFA); n=5 logopenic aphasia (LPA)). The face-to-face patient cohort comprised 64 patients (n=25 AD; n=12 bvFTD; n=9 SD; n=12 PNFA; n=6 LPA). Ten controls who previously participated in face-to-face research also took part remotely.Outcome measures The outcome measures comprised the strength of evidence under a Bayesian framework for differences in performances between testing environments on general neuropsychological and neurolinguistic measures.Results There was substantial evidence suggesting no difference across environments in both the healthy control and combined patient cohorts (including measures of working memory, single-word comprehension, arithmetic and naming; Bayes Factors (BF)01 >3), in the healthy control group alone (including measures of letter/category fluency, semantic knowledge and bisyllabic word repetition; all BF01 >3), and in the combined patient cohort alone (including measures of working memory, episodic memory, short-term verbal memory, visual perception, non-word reading, sentence comprehension and bisyllabic/trisyllabic word repetition; all BF01 >3). In the control cohort alone, there was substantial evidence in support of a difference across environments for tests of visual perception (BF01=0.0404) and monosyllabic word repetition (BF01=0.0487).Conclusions Our findings suggest that remote delivery of neuropsychological tests for dementia research is feasible.https://bmjopen.bmj.com/content/12/11/e064576.full |
| spellingShingle | Jason D Warren Jonathan D Rohrer Caroline Greaves Lucianne Dobson Rebecca L Bond Chris JD Hardy Sebastian J Crutch Jessica Jiang Elia Benhamou Mai-Carmen Requena-Komuro Suzie Barker Lucy Russell Emilie V Brotherhood Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individuals BMJ Open |
| title | Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individuals |
| title_full | Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individuals |
| title_fullStr | Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individuals |
| title_full_unstemmed | Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individuals |
| title_short | Remote versus face-to-face neuropsychological testing for dementia research: a comparative study in people with Alzheimer’s disease, frontotemporal dementia and healthy older individuals |
| title_sort | remote versus face to face neuropsychological testing for dementia research a comparative study in people with alzheimer s disease frontotemporal dementia and healthy older individuals |
| url | https://bmjopen.bmj.com/content/12/11/e064576.full |
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