High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

Abstract Background Ovarian cancer (OC) is the fifth most common malignant female cancer with a high mortality, mainly because of aggressive high-grade serous carcinomas (HGSOC), but also due to absence of specific early symptoms and effective detection strategies. The CXCL12-CXCR4 axis is considere...

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Bibliographic Details
Main Authors: Fabio Walther, Jana Ladina Berther, Alexandros Lalos, Michaela Ramser, Simone Eichelberger, Robert Mechera, Savas Soysal, Simone Muenst, Alberto Posabella, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A. Droeser, Jasmin Zeindler, Gad Singer
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Cancer
Subjects:
Ovarian cancer
CXCR4
PCXCR4
Tumor expression
Tumor infiltrating immune cells
Prognostic significance
Online Access:https://doi.org/10.1186/s12885-022-09374-x

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