Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect
The present work was undertaken to investigate the protective effects of Eryngium maritimum seeds extract (MEE) against CCl4 and cisplatin induced toxicity in rats. The levels of total phenolics and flavonoids were ca. 20 mg GAE/g and ca. 19 mg QE/g, respectively. Using HPLC twenty-one molecules wer...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617304425 |
| _version_ | 1818415641980305408 |
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| author | Houda Mejri Meriam Tir Anouar Feriani Lakhdhar Ghazouani Mohamed Salah Allagui Moufida Saidani-Tounsi |
| author_facet | Houda Mejri Meriam Tir Anouar Feriani Lakhdhar Ghazouani Mohamed Salah Allagui Moufida Saidani-Tounsi |
| author_sort | Houda Mejri |
| collection | DOAJ |
| description | The present work was undertaken to investigate the protective effects of Eryngium maritimum seeds extract (MEE) against CCl4 and cisplatin induced toxicity in rats. The levels of total phenolics and flavonoids were ca. 20 mg GAE/g and ca. 19 mg QE/g, respectively. Using HPLC twenty-one molecules were identified. MEE showed important in vitro antioxidant activities. Results demonstrated that MEE-treatment restored the increased activities of AST, ALT, LDH and ALP and the high levels of serum creatinine, urea and uric acid levels induced by CCl4 and cisplatin treatment. Moreover, MEE presented important in vivo antioxidant activities; increased the activities of CAT, SOD and GPx and decreased the TBARS and protein carbonyl contents. The histopathological studies suggested that MEE clearly alleviated the degree of tissues fibrosis. The obtained results highlighted the potential use of E. maritimum as a source of bioactive compounds with hepatoprotective and nephroprotective advantages. |
| first_indexed | 2024-12-14T11:38:14Z |
| format | Article |
| id | doaj.art-ef81358b616b4dd08c343029982337d6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T11:38:14Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ef81358b616b4dd08c343029982337d62022-12-21T23:02:56ZengElsevierJournal of Functional Foods1756-46462017-10-0137363372Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effectHouda Mejri0Meriam Tir1Anouar Feriani2Lakhdhar Ghazouani3Mohamed Salah Allagui4Moufida Saidani-Tounsi5Laboratoire des Plantes Aromatiques et Médicinales, Centre de Biotechnologie de Borj-Cédria, Hammam-Lif, Tunisia; Corresponding author.UR de Physiologie et Environnement Aquatique, Faculté des Sciences de Tunis, Université Tunis EL Manar, 2092 Tunis, TunisiaUnité de Biochimie Macromoléculaire et Génétique, Faculté des Sciences de Gafsa, cité Zarroug, Université de Gafsa, 2112 Gafsa, Tunisia; Laboratoire d’Ecophysiologie Animale, Faculté des Sciences, 3018 Sfax, TunisiaUnité de Biochimie Macromoléculaire et Génétique, Faculté des Sciences de Gafsa, cité Zarroug, Université de Gafsa, 2112 Gafsa, TunisiaLaboratoire d’Ecophysiologie Animale, Faculté des Sciences, 3018 Sfax, TunisiaLaboratoire des Plantes Aromatiques et Médicinales, Centre de Biotechnologie de Borj-Cédria, Hammam-Lif, TunisiaThe present work was undertaken to investigate the protective effects of Eryngium maritimum seeds extract (MEE) against CCl4 and cisplatin induced toxicity in rats. The levels of total phenolics and flavonoids were ca. 20 mg GAE/g and ca. 19 mg QE/g, respectively. Using HPLC twenty-one molecules were identified. MEE showed important in vitro antioxidant activities. Results demonstrated that MEE-treatment restored the increased activities of AST, ALT, LDH and ALP and the high levels of serum creatinine, urea and uric acid levels induced by CCl4 and cisplatin treatment. Moreover, MEE presented important in vivo antioxidant activities; increased the activities of CAT, SOD and GPx and decreased the TBARS and protein carbonyl contents. The histopathological studies suggested that MEE clearly alleviated the degree of tissues fibrosis. The obtained results highlighted the potential use of E. maritimum as a source of bioactive compounds with hepatoprotective and nephroprotective advantages.http://www.sciencedirect.com/science/article/pii/S1756464617304425Eryngium maritimumPhytochemicalAntioxidantHepatoprotectiveNephroptotectiveAntifibrotic |
| spellingShingle | Houda Mejri Meriam Tir Anouar Feriani Lakhdhar Ghazouani Mohamed Salah Allagui Moufida Saidani-Tounsi Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect Journal of Functional Foods Eryngium maritimum Phytochemical Antioxidant Hepatoprotective Nephroptotective Antifibrotic |
| title | Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect |
| title_full | Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect |
| title_fullStr | Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect |
| title_full_unstemmed | Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect |
| title_short | Does Eryngium maritimum seeds extract protect against CCl4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect |
| title_sort | does eryngium maritimum seeds extract protect against ccl4 and cisplatin induced toxicity in rats preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect |
| topic | Eryngium maritimum Phytochemical Antioxidant Hepatoprotective Nephroptotective Antifibrotic |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617304425 |
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