Discordant Hepatitis B Serology in Twins Despite Active and Passive Immunoprophylaxis: A Case Report
Hepatitis B virus (HBV) infection is still one of the most important causes of liver disease. In highly endemic areas, infection occurs mainly in infancy and early childhood with mother-to-child transmission, accounting for more than half of chronic infections. In this manuscript, discordant manifes...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2014-06-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2014-19-02-091-095.pdf |
| _version_ | 1797923436932104192 |
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| author | Tuğba SARI Süda TEKİN KORUK |
| author_facet | Tuğba SARI Süda TEKİN KORUK |
| author_sort | Tuğba SARI |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) infection is still one of the most important causes of liver disease. In highly endemic areas, infection occurs mainly in infancy and early childhood with mother-to-child transmission, accounting for more than half of chronic infections. In this manuscript, discordant manifestations and evolution of HBV infection in a pair of monozygotic twins are reported. A 8-year-old child was admitted to our clinic with HbsAg positivity. She had a history of normal vaginal delivery without any complications. HBV vaccine and HBIG were administered to the newborn within the first hour of life. HBV vaccination series were completed with the administration of second and third doses during one month and 6 months of age. HBsAg positivity was determined in a different center and referred to our clinic. In laboratory analysis, HBsAg was (+), anti-HBs (-), HBeAg (-), anti-HBe: (+), AST was 39 IU/L, ALT: 20 IU/L and HBV-DNA: 203 IU/mL by real time polymerase chain reaction (RT-PCR). However, in the tests of the twin sister of the patient HBsAg was (-), anti-HBs > 1000 mIU/mL. In the mother’s laboratory analysis HBsAg was (+), anti-HBe (-), HBeAg (+), HBV-DNA > 108 IU/mL, AST: 34 IU/L, ALT: 34 IU/L. In order to decrease the rate of perinatal transmission, an oral antiviral agent may be administered during the third trimester of the pregnancy in order to reduce the level of maternal viremia. Although administration of HBIG with hepatitis B vaccine is the most effective way of preventing the perinatal transmission, HBV infection may occur in 5%-10% of cases. |
| first_indexed | 2024-04-10T14:46:21Z |
| format | Article |
| id | doaj.art-ef85a02a5f3d4a88b88da3c3ff826750 |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T14:46:21Z |
| publishDate | 2014-06-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-ef85a02a5f3d4a88b88da3c3ff8267502023-02-15T16:07:53ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X2014-06-011929195Discordant Hepatitis B Serology in Twins Despite Active and Passive Immunoprophylaxis: A Case ReportTuğba SARI0Süda TEKİN KORUK1Clinic of Infectious Diseases and Clinical Microbiology, Dr. Abdullah Sayiner Buldan Chest Diseases Hospital, Denizli, TurkeyDepartment of Infectious Diseases and Clinical Microbioloy, Faculty of Medicine, University of Harran, Sanliurfa, TurkeyHepatitis B virus (HBV) infection is still one of the most important causes of liver disease. In highly endemic areas, infection occurs mainly in infancy and early childhood with mother-to-child transmission, accounting for more than half of chronic infections. In this manuscript, discordant manifestations and evolution of HBV infection in a pair of monozygotic twins are reported. A 8-year-old child was admitted to our clinic with HbsAg positivity. She had a history of normal vaginal delivery without any complications. HBV vaccine and HBIG were administered to the newborn within the first hour of life. HBV vaccination series were completed with the administration of second and third doses during one month and 6 months of age. HBsAg positivity was determined in a different center and referred to our clinic. In laboratory analysis, HBsAg was (+), anti-HBs (-), HBeAg (-), anti-HBe: (+), AST was 39 IU/L, ALT: 20 IU/L and HBV-DNA: 203 IU/mL by real time polymerase chain reaction (RT-PCR). However, in the tests of the twin sister of the patient HBsAg was (-), anti-HBs > 1000 mIU/mL. In the mother’s laboratory analysis HBsAg was (+), anti-HBe (-), HBeAg (+), HBV-DNA > 108 IU/mL, AST: 34 IU/L, ALT: 34 IU/L. In order to decrease the rate of perinatal transmission, an oral antiviral agent may be administered during the third trimester of the pregnancy in order to reduce the level of maternal viremia. Although administration of HBIG with hepatitis B vaccine is the most effective way of preventing the perinatal transmission, HBV infection may occur in 5%-10% of cases.http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2014-19-02-091-095.pdfHepatitis BTwinsPerinatal careTransmission |
| spellingShingle | Tuğba SARI Süda TEKİN KORUK Discordant Hepatitis B Serology in Twins Despite Active and Passive Immunoprophylaxis: A Case Report Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi Hepatitis B Twins Perinatal care Transmission |
| title | Discordant Hepatitis B Serology in Twins Despite Active and Passive Immunoprophylaxis: A Case Report |
| title_full | Discordant Hepatitis B Serology in Twins Despite Active and Passive Immunoprophylaxis: A Case Report |
| title_fullStr | Discordant Hepatitis B Serology in Twins Despite Active and Passive Immunoprophylaxis: A Case Report |
| title_full_unstemmed | Discordant Hepatitis B Serology in Twins Despite Active and Passive Immunoprophylaxis: A Case Report |
| title_short | Discordant Hepatitis B Serology in Twins Despite Active and Passive Immunoprophylaxis: A Case Report |
| title_sort | discordant hepatitis b serology in twins despite active and passive immunoprophylaxis a case report |
| topic | Hepatitis B Twins Perinatal care Transmission |
| url | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2014-19-02-091-095.pdf |
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