A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry
Natural products are increasingly being considered “critical and important” in drug discovery paradigms as a number of them such as camptothecin, penicillin, and vincristine serve as “lead molecules” for the discovery of potent compounds of therapeutic interests namely irinotecan, penicillin G, vinb...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123214001350 |
| _version_ | 1819028123358855168 |
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| author | Vikas Sharma Prabodh C. Sharma Vipin Kumar |
| author_facet | Vikas Sharma Prabodh C. Sharma Vipin Kumar |
| author_sort | Vikas Sharma |
| collection | DOAJ |
| description | Natural products are increasingly being considered “critical and important” in drug discovery paradigms as a number of them such as camptothecin, penicillin, and vincristine serve as “lead molecules” for the discovery of potent compounds of therapeutic interests namely irinotecan, penicillin G, vinblastine respectively. Derived compounds of pharmacological interests displayed a wide variety of activity viz. anticancer, anti-inflammatory, antimicrobial, anti-protozoal, etc.; when modifications or derivatizations are performed on a parent moiety representing the corresponding derivatives. Pyridoacridine is such a moiety which forms the basic structure of numerous medicinally important natural products such as, but not limited to, amphimedine, ascididemin, eilatin, and sampangine. Interestingly, synthetic analogues of natural pyridoacridine exhibit diverse pharmacological activities and in view of these, natural pyridoacridines can be considered as “lead compounds”. This review additionally provides a brief but critical account of inherent structure activity relationships among various subclasses of pyridoacridines. Furthermore, the current aspects and future prospects of natural pyridoacridines are detailed for further reference and consideration. |
| first_indexed | 2024-12-21T05:53:22Z |
| format | Article |
| id | doaj.art-ef85b561c9f147328e378cc002d174aa |
| institution | Directory Open Access Journal |
| issn | 2090-1232 2090-1224 |
| language | English |
| last_indexed | 2024-12-21T05:53:22Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-ef85b561c9f147328e378cc002d174aa2022-12-21T19:13:54ZengElsevierJournal of Advanced Research2090-12322090-12242015-01-0161637110.1016/j.jare.2014.11.002A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistryVikas Sharma0Prabodh C. Sharma1Vipin Kumar2Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, IndiaInstitute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, IndiaInstitute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, IndiaNatural products are increasingly being considered “critical and important” in drug discovery paradigms as a number of them such as camptothecin, penicillin, and vincristine serve as “lead molecules” for the discovery of potent compounds of therapeutic interests namely irinotecan, penicillin G, vinblastine respectively. Derived compounds of pharmacological interests displayed a wide variety of activity viz. anticancer, anti-inflammatory, antimicrobial, anti-protozoal, etc.; when modifications or derivatizations are performed on a parent moiety representing the corresponding derivatives. Pyridoacridine is such a moiety which forms the basic structure of numerous medicinally important natural products such as, but not limited to, amphimedine, ascididemin, eilatin, and sampangine. Interestingly, synthetic analogues of natural pyridoacridine exhibit diverse pharmacological activities and in view of these, natural pyridoacridines can be considered as “lead compounds”. This review additionally provides a brief but critical account of inherent structure activity relationships among various subclasses of pyridoacridines. Furthermore, the current aspects and future prospects of natural pyridoacridines are detailed for further reference and consideration.http://www.sciencedirect.com/science/article/pii/S2090123214001350AmphimedineAnalogueAscidideminLead compoundNaturalPyridoacridine |
| spellingShingle | Vikas Sharma Prabodh C. Sharma Vipin Kumar A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry Journal of Advanced Research Amphimedine Analogue Ascididemin Lead compound Natural Pyridoacridine |
| title | A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry |
| title_full | A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry |
| title_fullStr | A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry |
| title_full_unstemmed | A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry |
| title_short | A mini review on pyridoacridines: Prospective lead compounds in medicinal chemistry |
| title_sort | mini review on pyridoacridines prospective lead compounds in medicinal chemistry |
| topic | Amphimedine Analogue Ascididemin Lead compound Natural Pyridoacridine |
| url | http://www.sciencedirect.com/science/article/pii/S2090123214001350 |
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