Clinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facility
Abstract Background Few data are available on the characteristics of infective endocarditis (IE) cases in Egypt. The aim of this work is to describe the characteristics and outcomes of IE patients and evaluate the temporal changes in IE diagnostic and therapeutic aspects over 11 years. Results The I...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-09-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43044-019-0018-y |
| _version_ | 1828554987789090816 |
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| author | Hussein Hassan Rizk Ahmed Adel Elamragy Ghada Sayed Youssef Marwa Sayed Meshaal Ahmad Samir Ahmed ElSharkawy Karim Said Hussien Heshmat Kassem Mervat Gaber Elanany Amani Ali El-Kholy Al Sayed Akl Soheir M. Mahfouz Khaled Ali Sorour |
| author_facet | Hussein Hassan Rizk Ahmed Adel Elamragy Ghada Sayed Youssef Marwa Sayed Meshaal Ahmad Samir Ahmed ElSharkawy Karim Said Hussien Heshmat Kassem Mervat Gaber Elanany Amani Ali El-Kholy Al Sayed Akl Soheir M. Mahfouz Khaled Ali Sorour |
| author_sort | Hussein Hassan Rizk |
| collection | DOAJ |
| description | Abstract Background Few data are available on the characteristics of infective endocarditis (IE) cases in Egypt. The aim of this work is to describe the characteristics and outcomes of IE patients and evaluate the temporal changes in IE diagnostic and therapeutic aspects over 11 years. Results The IE registry included 398 patients referred to the Endocarditis Unit of a tertiary care facility with the diagnosis of possible or definite IE. Patients were recruited over two periods; period 1 (n = 237, 59.5%) from February 2005 to December 2011 and period 2 (n = 161, 40.5%) from January 2012 to September 2016. An electronic database was constructed to include information on patients’ clinical and microbiological characteristics as well as complications and mortality. The median age was 30 years and rheumatic valvular heart disease was the commonest underlying cardiac disease (34.7%). Healthcare-associated IE affected 185 patients (46.5%) and 275 patients (69.1%) had negative blood cultures. The most common complications were heart failure (n = 148, 37.2%), peripheral embolization (n = 133, 33.4%), and severe sepsis (n = 100, 25.1%). In-hospital mortality occurred in 108 patients (27.1%). Period 2 was characterized by a higher prevalence of injection drug use-associated IE (15.5% vs. 7.2%, p = 0.008), a higher staphylococcal IE (50.0% vs. 35.7%, p = 0.038), lower complications (31.1% vs. 45.1%, p = 0.005), and a lower in-hospital mortality (19.9% vs. 32.1%, p = 0.007). Conclusion This Egyptian registry showed high rates of culture-negative IE, complications, and in-hospital mortality in a largely young population of patients. Improvements were noted in the rates of complications and mortality in the second half of the reporting period. |
| first_indexed | 2024-12-12T05:45:27Z |
| format | Article |
| id | doaj.art-ef86a35f2ad542519487e8cbafe1c97f |
| institution | Directory Open Access Journal |
| issn | 2090-911X |
| language | English |
| last_indexed | 2024-12-12T05:45:27Z |
| publishDate | 2019-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-ef86a35f2ad542519487e8cbafe1c97f2022-12-22T00:35:48ZengSpringerOpenThe Egyptian Heart Journal2090-911X2019-09-017111910.1186/s43044-019-0018-yClinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facilityHussein Hassan Rizk0Ahmed Adel Elamragy1Ghada Sayed Youssef2Marwa Sayed Meshaal3Ahmad Samir4Ahmed ElSharkawy5Karim Said6Hussien Heshmat Kassem7Mervat Gaber Elanany8Amani Ali El-Kholy9Al Sayed Akl10Soheir M. Mahfouz11Khaled Ali Sorour12Department of Cardiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiothoracic Surgery, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Clinical Pathology and Microbiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Clinical Pathology and Microbiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiothoracic Surgery, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Pathology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityDepartment of Cardiology, Kasr Al Aini Hospital, Faculty of Medicine, Cairo UniversityAbstract Background Few data are available on the characteristics of infective endocarditis (IE) cases in Egypt. The aim of this work is to describe the characteristics and outcomes of IE patients and evaluate the temporal changes in IE diagnostic and therapeutic aspects over 11 years. Results The IE registry included 398 patients referred to the Endocarditis Unit of a tertiary care facility with the diagnosis of possible or definite IE. Patients were recruited over two periods; period 1 (n = 237, 59.5%) from February 2005 to December 2011 and period 2 (n = 161, 40.5%) from January 2012 to September 2016. An electronic database was constructed to include information on patients’ clinical and microbiological characteristics as well as complications and mortality. The median age was 30 years and rheumatic valvular heart disease was the commonest underlying cardiac disease (34.7%). Healthcare-associated IE affected 185 patients (46.5%) and 275 patients (69.1%) had negative blood cultures. The most common complications were heart failure (n = 148, 37.2%), peripheral embolization (n = 133, 33.4%), and severe sepsis (n = 100, 25.1%). In-hospital mortality occurred in 108 patients (27.1%). Period 2 was characterized by a higher prevalence of injection drug use-associated IE (15.5% vs. 7.2%, p = 0.008), a higher staphylococcal IE (50.0% vs. 35.7%, p = 0.038), lower complications (31.1% vs. 45.1%, p = 0.005), and a lower in-hospital mortality (19.9% vs. 32.1%, p = 0.007). Conclusion This Egyptian registry showed high rates of culture-negative IE, complications, and in-hospital mortality in a largely young population of patients. Improvements were noted in the rates of complications and mortality in the second half of the reporting period.http://link.springer.com/article/10.1186/s43044-019-0018-yEndocarditisRegistriesEgypt |
| spellingShingle | Hussein Hassan Rizk Ahmed Adel Elamragy Ghada Sayed Youssef Marwa Sayed Meshaal Ahmad Samir Ahmed ElSharkawy Karim Said Hussien Heshmat Kassem Mervat Gaber Elanany Amani Ali El-Kholy Al Sayed Akl Soheir M. Mahfouz Khaled Ali Sorour Clinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facility The Egyptian Heart Journal Endocarditis Registries Egypt |
| title | Clinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facility |
| title_full | Clinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facility |
| title_fullStr | Clinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facility |
| title_full_unstemmed | Clinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facility |
| title_short | Clinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facility |
| title_sort | clinical features and outcomes of infective endocarditis in egypt an 11 year experience at a tertiary care facility |
| topic | Endocarditis Registries Egypt |
| url | http://link.springer.com/article/10.1186/s43044-019-0018-y |
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