Caught in action: how MSCs modulate atherosclerotic plaque
Atherosclerosis (AS) is a medical condition marked by the stiffening and constriction of the arteries. This is caused by the accumulation of plaque, a substance made up of fat, cholesterol, calcium, and other elements present in the blood. Over time, this plaque solidifies and constricts the arterie...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1379091/full |
| _version_ | 1797243124037189632 |
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| author | Virginia Egea Virginia Egea |
| author_facet | Virginia Egea Virginia Egea |
| author_sort | Virginia Egea |
| collection | DOAJ |
| description | Atherosclerosis (AS) is a medical condition marked by the stiffening and constriction of the arteries. This is caused by the accumulation of plaque, a substance made up of fat, cholesterol, calcium, and other elements present in the blood. Over time, this plaque solidifies and constricts the arteries, restricting the circulation of oxygen-rich blood to the organs and other body parts. The onset and progression of AS involve a continuous inflammatory response, including the infiltration of inflammatory cells, foam cells derived from monocytes/macrophages, and inflammatory cytokines and chemokines. Mesenchymal stromal cells (MSCs), a type of multipotent stem cells originating from various body tissues, have recently been demonstrated to have a protective and regulatory role in diseases involving inflammation. Consequently, the transplantation of MSCs is being proposed as a novel therapeutic strategy for atherosclerosis treatment. This mini-review intends to provide a summary of the regulatory effects of MSCs at the plaque site to lay the groundwork for therapeutic interventions. |
| first_indexed | 2024-04-24T18:50:07Z |
| format | Article |
| id | doaj.art-ef876dbd0d50413c8619d7d536747cbf |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-24T18:50:07Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ef876dbd0d50413c8619d7d536747cbf2024-03-27T04:23:32ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-03-011210.3389/fcell.2024.13790911379091Caught in action: how MSCs modulate atherosclerotic plaqueVirginia Egea0Virginia Egea1Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, GermanyAtherosclerosis (AS) is a medical condition marked by the stiffening and constriction of the arteries. This is caused by the accumulation of plaque, a substance made up of fat, cholesterol, calcium, and other elements present in the blood. Over time, this plaque solidifies and constricts the arteries, restricting the circulation of oxygen-rich blood to the organs and other body parts. The onset and progression of AS involve a continuous inflammatory response, including the infiltration of inflammatory cells, foam cells derived from monocytes/macrophages, and inflammatory cytokines and chemokines. Mesenchymal stromal cells (MSCs), a type of multipotent stem cells originating from various body tissues, have recently been demonstrated to have a protective and regulatory role in diseases involving inflammation. Consequently, the transplantation of MSCs is being proposed as a novel therapeutic strategy for atherosclerosis treatment. This mini-review intends to provide a summary of the regulatory effects of MSCs at the plaque site to lay the groundwork for therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fcell.2024.1379091/fullMSCsatherosclerotic plaquescell-therapyTrojan horse approachmigration |
| spellingShingle | Virginia Egea Virginia Egea Caught in action: how MSCs modulate atherosclerotic plaque Frontiers in Cell and Developmental Biology MSCs atherosclerotic plaques cell-therapy Trojan horse approach migration |
| title | Caught in action: how MSCs modulate atherosclerotic plaque |
| title_full | Caught in action: how MSCs modulate atherosclerotic plaque |
| title_fullStr | Caught in action: how MSCs modulate atherosclerotic plaque |
| title_full_unstemmed | Caught in action: how MSCs modulate atherosclerotic plaque |
| title_short | Caught in action: how MSCs modulate atherosclerotic plaque |
| title_sort | caught in action how mscs modulate atherosclerotic plaque |
| topic | MSCs atherosclerotic plaques cell-therapy Trojan horse approach migration |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1379091/full |
| work_keys_str_mv | AT virginiaegea caughtinactionhowmscsmodulateatheroscleroticplaque AT virginiaegea caughtinactionhowmscsmodulateatheroscleroticplaque |