Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery
Thymoma is a tumor rarely reported in dogs and should be differentiated from mediastinal lymphoma. Clinical signs may have a late onset, and thymoma is often diagnosed when symptoms related to the space-occupying effect or paraneoplastic syndromes occur. CT and fine-needle aspirates or core biopsies...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/12/3444 |
| _version_ | 1797506975920029696 |
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| author | Marina Martano Paolo Buracco Emanuela Maria Morello |
| author_facet | Marina Martano Paolo Buracco Emanuela Maria Morello |
| author_sort | Marina Martano |
| collection | DOAJ |
| description | Thymoma is a tumor rarely reported in dogs and should be differentiated from mediastinal lymphoma. Clinical signs may have a late onset, and thymoma is often diagnosed when symptoms related to the space-occupying effect or paraneoplastic syndromes occur. CT and fine-needle aspirates or core biopsies are helpful in differential diagnosis, but flow cytometry may improve the pre-operative diagnostic ability. Concurrent paraneoplastic syndromes such as <i>myasthenia gravis</i> and hypercalcemia have been reported; however, their role as prognostic factors is not well determined. Surgical excision is the treatment of choice; adjuvant radiotherapy and/or chemotherapy may prolong survival in cases of incomplete excision or when a thymic carcinoma is diagnosed. Local recurrence and metastasis are infrequently reported; therefore, a long survival time is expected if the tumor is completely excised or if adjuvant therapy is undertaken. This article reports the authors’ experience with 28 dogs affected by 18 thymomas and 10 thymic carcinomas. The median overall survival in this series was 1173 days, and the median disease-free interval was 903 days. Dogs with thymic carcinoma had significantly shorter disease-free intervals and shorter, although not statistically significant, survival times. Dogs with Masaoka Stage III tumors had worse outcomes. |
| first_indexed | 2024-03-10T04:40:05Z |
| format | Article |
| id | doaj.art-ef8773a6dde144e3aea803cc0db47935 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T04:40:05Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-ef8773a6dde144e3aea803cc0db479352023-11-23T03:27:03ZengMDPI AGAnimals2076-26152021-12-011112344410.3390/ani11123444Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by SurgeryMarina Martano0Paolo Buracco1Emanuela Maria Morello2Department of Veterinary Medical Sciences, University of Parma, Strada del Taglio, 10, 43126 Parma, ItalyDepartment of Veterinary Sciences, University of Torino, Largo P. Braccini 2, Grugliasco, 10095 Torino, ItalyDepartment of Veterinary Sciences, University of Torino, Largo P. Braccini 2, Grugliasco, 10095 Torino, ItalyThymoma is a tumor rarely reported in dogs and should be differentiated from mediastinal lymphoma. Clinical signs may have a late onset, and thymoma is often diagnosed when symptoms related to the space-occupying effect or paraneoplastic syndromes occur. CT and fine-needle aspirates or core biopsies are helpful in differential diagnosis, but flow cytometry may improve the pre-operative diagnostic ability. Concurrent paraneoplastic syndromes such as <i>myasthenia gravis</i> and hypercalcemia have been reported; however, their role as prognostic factors is not well determined. Surgical excision is the treatment of choice; adjuvant radiotherapy and/or chemotherapy may prolong survival in cases of incomplete excision or when a thymic carcinoma is diagnosed. Local recurrence and metastasis are infrequently reported; therefore, a long survival time is expected if the tumor is completely excised or if adjuvant therapy is undertaken. This article reports the authors’ experience with 28 dogs affected by 18 thymomas and 10 thymic carcinomas. The median overall survival in this series was 1173 days, and the median disease-free interval was 903 days. Dogs with thymic carcinoma had significantly shorter disease-free intervals and shorter, although not statistically significant, survival times. Dogs with Masaoka Stage III tumors had worse outcomes.https://www.mdpi.com/2076-2615/11/12/3444dogthymomacanine thymic carcinomaparaneoplastic <i>myasthenia gravis</i>hypercalcemia of malignancythoracic surgery |
| spellingShingle | Marina Martano Paolo Buracco Emanuela Maria Morello Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery Animals dog thymoma canine thymic carcinoma paraneoplastic <i>myasthenia gravis</i> hypercalcemia of malignancy thoracic surgery |
| title | Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery |
| title_full | Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery |
| title_fullStr | Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery |
| title_full_unstemmed | Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery |
| title_short | Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery |
| title_sort | canine epithelial thymic tumors outcome in 28 dogs treated by surgery |
| topic | dog thymoma canine thymic carcinoma paraneoplastic <i>myasthenia gravis</i> hypercalcemia of malignancy thoracic surgery |
| url | https://www.mdpi.com/2076-2615/11/12/3444 |
| work_keys_str_mv | AT marinamartano canineepithelialthymictumorsoutcomein28dogstreatedbysurgery AT paoloburacco canineepithelialthymictumorsoutcomein28dogstreatedbysurgery AT emanuelamariamorello canineepithelialthymictumorsoutcomein28dogstreatedbysurgery |