The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus
ABSTRACT Objective: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. Subjects and methods: A total number of 134 T1DM patients a...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000400480&lng=en&tlng=en |
| _version_ | 1818558082157903872 |
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| author | Karla Simone Costa de Souza Marcela Abbott Galvão Ururahy Yonara Monique da Costa Oliveira Melina Bezerra Loureiro Heglayne Pereira Vital da Silva Raul Hernandes Bortolin André Ducati Luchessi Ricardo Fernando Arrais Rosário Dominguez Crespo Hirata Maria das Graças Almeida Mário Hiroyuki Hirata Adriana Augusto de Rezende |
| author_facet | Karla Simone Costa de Souza Marcela Abbott Galvão Ururahy Yonara Monique da Costa Oliveira Melina Bezerra Loureiro Heglayne Pereira Vital da Silva Raul Hernandes Bortolin André Ducati Luchessi Ricardo Fernando Arrais Rosário Dominguez Crespo Hirata Maria das Graças Almeida Mário Hiroyuki Hirata Adriana Augusto de Rezende |
| author_sort | Karla Simone Costa de Souza |
| collection | DOAJ |
| description | ABSTRACT Objective: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. Subjects and methods: A total number of 134 T1DM patients and 180 normoglycemic individuals (NG) aged 6-20 years were studied. Glycated hemoglobin and glucose levels were determined. Genotyping of LRP5 4037C>T (rs3736228) was performed. Results: T1DM patients showed poor glycemic control. Genotypes in the codominant (CT: OR = 2.99 [CI 95%: 1.71-5.24], p < 0.001; TT: OR = 5.34 [CI 95%: 1.05-2702], p < 0.001), dominant (CT + TT: OR = 3.16 [CI 95%: 1.84-5.43], p < 0.001) and log-additive (OR = 2.78 [CI 95%: 1.70-4.52], p < 0.001) models, and LRP5 4037T allele (OR = 2.88, [CI 95%: 1.78-4.77], p < 0.001) were associated with an increased risk of developing T1DM. LRP5 4037CT and CT+TT carriers in T1DM group showed higher concentrations of serum glucose and glycated hemoglobin when compared with CC carriers. Conclusion: The LRP5 4037C>T may represent a candidate for T1DM susceptibility, as well as poor glycemic control. |
| first_indexed | 2024-12-14T00:08:08Z |
| format | Article |
| id | doaj.art-ef8965f1dca64b0692004c5059f1f1bf |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-14T00:08:08Z |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-ef8965f1dca64b0692004c5059f1f1bf2022-12-21T23:25:54ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-429262448048410.20945/2359-3997000000057S2359-39972018000400480The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitusKarla Simone Costa de SouzaMarcela Abbott Galvão UrurahyYonara Monique da Costa OliveiraMelina Bezerra LoureiroHeglayne Pereira Vital da SilvaRaul Hernandes BortolinAndré Ducati LuchessiRicardo Fernando ArraisRosário Dominguez Crespo HirataMaria das Graças AlmeidaMário Hiroyuki HirataAdriana Augusto de RezendeABSTRACT Objective: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. Subjects and methods: A total number of 134 T1DM patients and 180 normoglycemic individuals (NG) aged 6-20 years were studied. Glycated hemoglobin and glucose levels were determined. Genotyping of LRP5 4037C>T (rs3736228) was performed. Results: T1DM patients showed poor glycemic control. Genotypes in the codominant (CT: OR = 2.99 [CI 95%: 1.71-5.24], p < 0.001; TT: OR = 5.34 [CI 95%: 1.05-2702], p < 0.001), dominant (CT + TT: OR = 3.16 [CI 95%: 1.84-5.43], p < 0.001) and log-additive (OR = 2.78 [CI 95%: 1.70-4.52], p < 0.001) models, and LRP5 4037T allele (OR = 2.88, [CI 95%: 1.78-4.77], p < 0.001) were associated with an increased risk of developing T1DM. LRP5 4037CT and CT+TT carriers in T1DM group showed higher concentrations of serum glucose and glycated hemoglobin when compared with CC carriers. Conclusion: The LRP5 4037C>T may represent a candidate for T1DM susceptibility, as well as poor glycemic control.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000400480&lng=en&tlng=enType 1 diabetes mellitusLRP54037C>Trs3736228 |
| spellingShingle | Karla Simone Costa de Souza Marcela Abbott Galvão Ururahy Yonara Monique da Costa Oliveira Melina Bezerra Loureiro Heglayne Pereira Vital da Silva Raul Hernandes Bortolin André Ducati Luchessi Ricardo Fernando Arrais Rosário Dominguez Crespo Hirata Maria das Graças Almeida Mário Hiroyuki Hirata Adriana Augusto de Rezende The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus Archives of Endocrinology and Metabolism Type 1 diabetes mellitus LRP5 4037C>T rs3736228 |
| title | The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus |
| title_full | The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus |
| title_fullStr | The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus |
| title_full_unstemmed | The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus |
| title_short | The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus |
| title_sort | low density lipoprotein receptor related protein 5 lrp5 4037c t polymorphism candidate for susceptibility to type 1 diabetes mellitus |
| topic | Type 1 diabetes mellitus LRP5 4037C>T rs3736228 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000400480&lng=en&tlng=en |
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